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You don’t want to bet against Patrick Mahomes when the betting world is giving him extra motivation.

The three-time Super Bowl champion is 10-3 straight up as an underdog since 2018, and bettors who wagered on him to win in these scenarios have received an impressive 87 percent return on investment.

Those betting $100 in each spot would be up $1,131, according to Action Network.

Is Mahomes going to get the opportunity to shock the sportsbooks again?

The Chiefs opened as a 1.5-point underdogs to start the week, but the betting public is backing the reigning back-to-back Super Bowl champions as the odds have dropped down to a pick em’.

An ESPN BET spokesperson tells The Post that the public has placed 87.9 percent of the betting money on the Chiefs to beat the 49ers in Week 7.

San Francisco is missing Christian McCaffrey, while backup Jordan Mason is questionable to play due to an AC joint sprain.

Awaiting Mahomes is budding star Brock Purdy, who has had a massive season while missing notable playmakers all season.

Perhaps this is finally the time for the Chiefs to lose as underdogs, as the 49ers (3-3) don’t want to fall back below .500 after grabbing the NFC West division lead.

Erich Richter is a brazilian jiu-jitsu blue belt but he has a black belt in MMA betting. During the football season he’s showcased massive profits at The Post in the player prop market the last two seasons. While constantly betting long shots, his return on investment is 30.15 percent since 2022.