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The quarterfinals at the 2025 U.S. Open begin Tuesday, and the card looks perfectly poised.

Jiri Lehecka will meet Carlos Alcaraz in one of the men’s quarterfinal matches, but the headliner is a showdown between Novak Djokovic and Taylor Fritz.

The women’s card is headlined by Aryna Sabalenka and Jessica Pegula, who are both favorites in their respective matches.

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Lehecka is a gamer and won’t be taken lightly by Alcaraz, but there’s no doubt that Fritz vs. Djokovic is the headliner of Tuesday’s schedule.

Fritz has been superb in 2025, but he’s 0-10 against Djokovic in his career, which is why the Serb is the favorite to win the match, according to Fanatics Sportsbook.

We’ll see if the American can finally break the hex under the bright lights of New York City.

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Michael Leboff is a long-suffering Islanders fan, but a long-profiting sports bettor with 10 years of experience in the gambling industry. He loves using game theory to help punters win bracket pools, find long shots, and learn how to beat the market in mainstream and niche sports.