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Week 1 NFL lines are out in May and surely someone is ready to place their bets on who will start their season off right.
The regular season’s opening game will be Sept. 4 on “Thursday Night Football” when the defending Super Bowl champion Eagles host the division rival Cowboys.
Philadelphia opens as a seven-point favorite in a potential shootout, while Dallas is +280 on the moneyline at BetMGM Sportsbook.
There will also be a Friday contest during Week 1 for the second straight year as the Chiefs are 2.5-point favorites against Jim Harbaugh’s Chargers for their clash in Brazil.
The reigning champions in each conference get a showcase game in prime time to open the season before a 13-game onslaught Sunday.
Patrick Mahomes needs better offensive line play in 2025. APWeek 1 NFL lines, odds
Cowboys vs. Eagles
Chiefs vs. Chargers (Brazil)
Cardinals vs. Saints
Buccaneers vs. Falcons
Panthers vs. Jaguars
Joe Burrow needs some defensive help if he is to see serous time as a contender. APBengals vs. Browns
Dolphins vs. Colts
Giants vs. Commanders
Brian Daboll is fighting for his job in 2025. Robert Sabo for the NY PostSteelers vs. Jets
Raiders vs. Patriots
Titans vs. Broncos
49ers vs. Seahawks
Lions vs. Packers
Texans vs. Rams
Ravens vs. Bills
Betting on the NFL?
- Read our expert guide on how to bet on the NFL
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- Get the BetMGM Bonus Code
Vikings vs. Bears
Why Trust New York Post Betting
Erich Richter is a brazilian jiu-jitsu blue belt but he has a black belt in MMA betting. During the football season he’s showcased massive profits at The Post in the player prop market the last two seasons. While constantly betting long shots, his return on investment is 30.15 percent since 2022.
