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Sometimes you have to hold your nose and bet the underdog. No matter how ugly it may be to watch, those backers are sitting on some profit this season.

Whether it was the Giants’ win against the Titans in Week 1 or the Seahawks over the Broncos, underdogs win every week, and there is value in backing those point spreads in the NFL no matter how fluky the game may turn out to be.

Thus far in 2022, underdogs are 17-13-1 against the spread for a profit of 2.4 units. Even more, the underdog won outright in 11 of those games, losing 19. Of course, there was that one tie between the Texans and Colts.

There are a few dogs worth targeting in Week 3; below, we break down the best bets.

We love a home underdog in a must-win game. If the Panthers lose this one, Matt Rhule might not make it out of the stadium. The offense has left a lot to be desired up until this point, and the Saints’ defense is not going to be very welcoming.

However, Jameis Winston is now battling a back injury and looked more like old Jameis last week, throwing three interceptions. The advanced data rates the Panthers a bit higher than New Orleans (Carolina is 19th in overall DVOA, while the Saints are 22nd) and have the benefit of playing at home. It is past time that Mayfield gets Christian McCaffrey and DJ Moore heavily involved in the offense. Expect Rhule to throw everything at this game in a must-win for his career. Take moneyline at +125 (BetMGM) or better.

Carson Wentz revenge game? Everyone is talking about Jalen Hurts’ leap into the elite tier of NFL quarterbacks, and his MVP odds reflect exactly that. But are we underestimating the Commanders in Week 3 at home?

Their offense is absolutely loaded with a wide receiver room that includes Terry McLaurin, Curtis Samuel and rookie stud Jahan Dotson. We all know that Wentz has his issues with turnovers, but as 6.5-point underdogs at home, this could be an excellent spot to buy the dip. Admittedly, an additional half-point to get it to seven would be ideal, so keep an eye on it as the week continues. If it gets to +7, this is one of the best bets of the week.

Regardless, the Commanders are live dogs this weekend on the moneyline (+235, FanDuel) and are near the top of the league in most offensive categories. Not coincidentally, the Eagles are also near the top in the league in yards-per-play, third-down conversion percentage and total points scored. Washington’s defense is abysmal, so expect a back-and-forth shootout for this one.

If Wentz keeps the ball out of Darius Slay and Co.’s hands, this is an upset spot come Sunday.

Everyone is on the Giants bandwagon and ready to crown Brian Daboll as the Coach of the Year. With Kayvon Thibodeaux potentially able to make his NFL debut, the Giants are favorites on “Monday Night Football” at home.

But you might have seen Micah Parsons and Demarcus Lawrence terrorizing Joe Burrow for the entirety of their game in Week 2. Burrow was sacked on 14% of pass attempts and the Cowboys are third in the NFL in sacks with eight. The skill difference between Daniel Jones and Rush is, honestly, maybe not not much.

According to the Action Network’s Sean Koerner, the downgrade from Prescott to Rush is just 4.5 points against the spread, which is slightly above average. The Cowboys would likely have been more than a field-goal favorite at full health. Take the Cowboys here on the spread, as it could be a low-scoring affair. The moneyline is worth a bet at +110 (Caesars) or better.