The Boston Red Sox have MLB’s best road winning percentage on the road, but are just 20-17 at Fenway Park as they welcome the New York Yankees on Friday night.

Red Sox pitcher Martin Perez has a 6.68 ERA at home, allowing 1.7 home runs per nine innings and a .313 opponents batting average.

Domingo German has given up a combined 11 runs in his last two starts for the Yankees, but aside from this patch has been solid. He had allowed three runs or fewer in 10 of his first 11 starts of the season. German has served up two home runs in 34¹/₃ innings on the road compared to 12 homers in 34²/₃ innings at home. And his ERA is a full point lower outside The Bronx.

The Yankees’ bullpen ranks fourth in MLB in both ERA and fewest walks per nine innings issued, and their offense entered Thursday having scored at least five runs in 10 of their previous 14 games.

With the Red Sox having given up at least five runs in 12 of their previous 14 games entering Thursday and having allowed at least five runs in six of Perez’s eight home starts, the Yankees will strike first in this series.

The play: Yankees, +110.