Oprah axed Rosie O’Donnell’s talk show yesterday, just five months after the gabfest’s debut.

The last episode of “The Rosie Show” will be taped Tuesday, the day before O’Donnell turns 50, and will air on March 30, the Opray Winfrey Network said.

“As I have learned in the last 15 months, a new network launch is always a challenge,” Winfrey said.

O’Donnell put her $2.5 million 6,000-square-foot Chicago home up for sale in early March, less than six months after she bought it, according to Crain’s Chicago Business.