If it wasn’t the one-handed catch by Keelan Cole early, it was the strip-sack by Dante Fowler late. From kickoff to the last collision, the Jaguars jumped the Patriots, spun them around and watched as the reigning AFC champions blew their tops.

Cole ran up the tunnel after scoring one touchdown. Dede Westbrook broke off a 62-yard run on another score. It was Week 2, but Playoff Blake Bortles was activated, completing 29-of-46 passes for 377 yards and four touchdowns. His counterpart, Tom Brady, was limited to 234 yards and a pair of touchdowns.

“[Bortles] was balling, man,” Jaguars cornerback A.J. Bouye said.

It was a rematch of the AFC title game, and Jacksonville played like a unit with vengeance in mind. It was also a statement that the Jags are well established now.

“We’re here and we’re not letting up,” Bouye said.

The Jaguars fell to the Patriots in January, but they have proven single-minded in pursuing a Super Bowl berth of their own. In staking claim to a 14-0 lead in the first quarter, Jacksonville (2-0) unsettled the Patriots. Brady and offensive coordinator Josh McDaniels fumed on the sideline before the second quarter started. Jacksonville continued to press, building the lead to 24-3.

“Everyone needs to do a better job,” Brady said.

Brady was surrounded by pressure. With 12:38 left in the game, Jacksonville led 24-13 and the Patriots needed 9 yards on third down. Fowler rushed from Brady’s right side and blew past right tackle LaAdrian Waddle. As he neared Brady, Fowler reached out right his right hand and stripped the reigning MVP of the ball. Fowler finished it off by securing the ball and giving the Jaguars another possession to stave off the Patriots and win, 31-20.

Foxborough remains the benchmark for AFC competition, but the road to the Super Bowl may very well run through Jacksonville this winter.

It was the second game without running back Le’Veon Bell, and this time Pittsburgh took a loss at home.

The Steelers insist that they can win games without Bell, who remains a holdout due to a contract dispute, but two games have been played, and victory has eluded Pittsburgh. Miscues marred the team’s efforts Sunday.

Frustrated by the opening tie in Cleveland, Pittsburgh fans booed the home team Sunday as Kansas City came to Heinz Field, scored the game’s first 21 points, then watched the Steelers rally to tie it by halftime. Kansas City outlasted the Steelers to walk out with a 42-37 victory. Backup running back James Conner carried the ball eight times for 17 yards.

“It’s not fun, but it’s still early,” Roethlisberger said. “It’s a mirror, gut check or whatever you want to call it. So we will see how everybody is going to respond.”

Without Bell to hand off to, Roethlisberger attempted 35 passes in the first half. He kept the Steelers within striking distance after falling behind by three touchdowns. Still, Roethlisberger could not match the output of Chiefs quarterback Patrick Mahomes, who notched six touchdowns.

You are the 49ers — six-point favorites — and you are beating the Lions by 10 points with less than four minutes on the clock.

Beware the back-door cover. Michael Roberts hauls in a 15-yard pass from Matthew Stafford for a touchdown to conclude a 12-play drive and the game concludes 30-27.

It goes down as a touchback in the annals, but Taiwan Jones, a Buffalo returner, left the field bloodied as the new face of the game’s violent toll Sunday afternoon. Jones recovered a muffed punt in his own end zone during the Bills’ loss to the Chargers, and eyed an outlet to advance the ball. Before he could get out, one defender ripped his helmet off and Chargers linebacker Uchenna Nwosu, flying in helmet first, cracked the helmetless Jones in the temple. “It was tough on Uchenna. It’s his job to go down and make the play and that’s what he did,” Chargers coach Anthony Lynn said. “The referees, they are not perfect and sometimes calling these games in real speed is difficult, but that should’ve been blown [dead] when the helmet came off.” … Another collision could have been avoided in Atlanta, but Falcons defensive back Damontae Kazee came in kamikaze style on Panthers quarterback Cam Newton, who had given himself up, and struck Newton with a helmet-to-helmet blow. Kazee was ejected from the game.

1. Patrick Mahomes
No one threw a better ball Sunday as he completed 23 of 28 passes for 326 yards and six touchdowns. He is the first player in NFL history to throw a combined 10 TD passes in his first three games.

2. Kirk Cousins
Minnesota’s new leader looked the part of the franchise quarterback when he put up 425 yards in leading the Vikes to a 29-29 tie in Green Bay. A lone pick was his only flaw.

3. Keelan Cole
It wasn’t just the one-handed catch. Cole caught seven balls from Blake Bortles for 116 yards in beating the Patriots at home.

“I have so many emotions running through as far as what a terrible call it was. At the same time, I don’t know what else to do. I don’t know. You let me know. You tell me. Did I put pressure on him? I thought I hit him within his waist to chest, I got my head across, put my hands down. To call it at that point in the game is unbelievable.”

— Packers linebacker Clay Matthews after being called for roughing the passer, which allowed Minnesota to keep late drive alive

— Drew Loftis