The Cowboys’ disastrous Week 1 performance took a nightmarish turn in the final minutes.

Dak Prescott exited Dallas’ 19-3 loss to the Buccaneers late in the fourth quarter with a right hand injury. Owner Jerry Jones told reporters after the game that it will require surgery and that he will miss at least several weeks, according to The Athletic.

Head coach Mike McCarthy said the injury is “significant” and that the team will know more about the severity on Monday, per NFL Media.

“It’s very disappointing,” Prescott said, per the outlet. “But injuries happen. You can’t necessarily control it. It’s just unfortunate, obviously going to miss some time, not be there for my team. That’s what hurts more than anything, especially after the start we just put out there. Wanting to be able to respond and not necessarily having that opportunity for several weeks. Yeah, it’s unfortunate, but I’ll do what I’ve always done any time adversity comes. Take it on headfirst, give it my best, and I’m sure I’ll come out of this thing better.”

After getting his hand and thumb looked at by trainers on the sideline, Prescott jogged toward the locker room. He was undergoing X-rays before the final whistle, according to NBC’s broadcast. Prescott was replaced by Cooper Rush.

Struggling to get any rhythm on offense all night, Prescott completed just 14 of 29 passes for 134 yards and an interception before the injury.

It’s the latest in a line of injury concerns for Prescott, who earlier this week tweaked his ankle — the same ankle that he suffered a season-ending compound fracture and dislocation in 2020.

In 10 career games with the Cowboys since being signed as an undrafted free agent out of Central Michigan in 2017, Rush has completed 31 of 50 passes for 424 yards, three touchdowns and an interception.

The Cowboys do not currently have a third quarterback on the roster.