WIMBLEDON — Eleventh-seeded John Isner, the highest-ranked American man, blew a match point, wasted a two-sets-to-one lead, dropped a tiebreaker on grass, and bid a 6-4, 6-7 (7), 3-6, 7-6 (7), 7-5 farewell to Wimbledon in the first round against 73rd-ranked Alejandro Falla of Colombia yesterday.

Isner is best known for winning the longest match in tennis history, 70-68 in the fifth after more than 11 hours, against Nicolas Mahut at Wimbledon in 2010.

“I didn’t put my opponent away. I had my chances, and I didn’t do it. It’s all on me. Was just not great on my part.”