Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information.
There’s no room for underdogs in 2024.
After a bizarre March Madness tournament last year that was dominated by strange variances and underdogs reigning supreme, it’s all about the favorites this year,
Goliath smashed David early on, as all the top-two seeds advanced to the Sweet 16.
Beginning Thursday, the viewing public is graced with some incredible matchups including No. 2 vs. No. 3 matchups in the Midwest and East Regions.
Below are the odds for all eight matchups ahead of the Sweet 16.
Ramon Walker Jr. #3 of the Houston Cougars. Getty Images
March Madness Sweet 16 odds
March Madness Sweet 16 predictions
It’s tough to look at this field and really dig into an underdog you can sink your teeth into as a contender.
The UConn Huskies haven’t just looked good; they’ve looked flawless in the first two rounds.
For all the bluster ahead of the tournament, especially those who have pointed to the East Region being the region of death, UConn is still a massive 10.5-point favorite against the San Diego State Aztecs.
The Duke Blue Devils are slight underdogs to the Houston Cougars. Getty ImagesUConn has dropped from +360 to +210 since the bracket was announced.
Meanwhile, the Houston Cougars have hardly moved despite two victories, still hanging at +550 odds.
Houston’s near-disaster against the Texas A&M Aggies is a legitimate concern, as the Cougars face the Duke Blue Devils this week.
Betting on March Madness 2025?#
- Read our How to Bet on March Madness guide
- Get bonus bets and promos from the best March Madness betting sites
- Download The Post’s blank and complete NCAA brackets
Are they destined for a dance with the Huskies?
Not on the Blue Devils’ watch.
Duke will be the lone underdog to win outright of the eight Sweet 16 games this week.
PICK: Duke Blue Devils ML (+152, FanDuel)
