Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information.
The Tigers can’t lose.
Since dropping that tough season-opening matchup against Georgia, Clemson has racked up six consecutive victories, sitting atop the ACC standings with a 5-0 conference record.
Cade Klubnik has thrown 20 touchdowns during the stretch.
The Tigers have scored 40-plus points in five separate games.
They’ve out-scored their opponents 291-127.
But I think they’re overvalued entering Saturday’s matchup with a sneaky-tough Louisville squad.
Louisville vs. Clemson odds
Louisville vs. Clemson prediction
(7:30 p.m. ET, ESPN)
Sure, the Tigers have looked dominant.
They’ve also played nobody.
The past six wins have come against App State, NC State, Stanford, Florida State, Wake Forest and Virginia, six squads with a combined 13-29 record against FBS opponents.
They also benefitted from a +10 turnover differential across the six victories, perhaps inflating some of those blowouts.
Meanwhile, Louisville has battled 8-0 Miami (FL), 7-1 Notre Dame and 7-1 SMU in the past month.
The Cardinals have lost three of their past five, but those were three one-possession losses to three teams in the College Football Playoff hunt.
I don’t trust Louisville’s defense, but Tyler Shough is dealing, leading an offense that ranks eighth nationally in EPA per Dropback.
Tyler Shough #9 of the Louisville Cardinals passes the ball during the second half of a game against the Boston College Eagles at Alumni Stadium on October 25, 2024 in Chestnut Hill, Massachusetts. Getty ImagesAnd top running back Isaac Brown has amassed 650 rushing yards and six scores at nearly eight yards per carry.
If the Cardinals’ offense can score a combined 96 points against the Hurricanes, Irish and Mustangs, they can score against a Tigers stop unit that ranks 76th nationally in EPA per Play allowed.
Betting on College Football?
- Check out the best College Football betting sites
- Read our expert’s guide on how to bet on College Football
- Get the latest College Football National Championship winner odds
Louisville vs. Clemson pick
The schematic, on-the-field matchup isn’t great, but I expect Clemson to struggle against a clear step-up in competition.
Meanwhile, Louisville has proven it can keep pace with anybody.
10 points are too many for the Cardinals to be catching.
Pick: Louisville +10.5 (-110, bet365)
Why Trust New York Post Betting
Tanner McGrath has been a professional sports handicapper since 2018. Specializing in college sports and baseball, he’s a diehard fan of the Vermont Catamounts, the Miami Marlins and any home underdog. He found himself on the wrong side of the Miami Miracle in 2018, but made up for it four years later by hitting a 40/1 long shot on Sandy Alcantara to win the NL Cy Young.
