VSiN’s college football handicapper drills into betting angles for his best games of the weekend:

Clemson (-5.5, O/U 50.5) at Notre Dame: In the last two games, Clemson has been favored by a combined 74 points against Boston College and Syracuse. The Tigers struggled at times in both, especially early, before finding a rhythm in the second half. Still, they fell well short of covering.

Notre Dame hasn’t exactly been dazzling against the spread either. The Irish are 1-3 ATS in the last four and historically have struggled in games of this magnitude. Since 1994, according to handicapper Brad Powers, Notre Dame is 4-40 overall and 11-32-1 ATS when playing teams that finished in the AP Top 10. Yikes.

And while I tend not to overreact to certain historical trends, the picture has been pretty clear. Clemson has more talent, including Travis Etienne, one of the most explosive players college football has seen in 10 years. And even though Clemson doesn’t have Trevor Lawrence, the best player in college football, Notre Dame might have its hands full.

Georgia (-3.5, 52.5) vs. Florida: This game formerly recognized as the World’s Largest Outdoor Cocktail Party is ripe with intrigue even if there will be no party.

Florida’s last few weeks included a COVID-19 outbreak and a massive brawl with Missouri, a brawl in which coach Dan Mullen was a central part and for which he has been fined. But the offense still has one of the nation’s best quarterbacks in Kyle Trask. At his disposal is wideout Kadarius Toney and tight end Kyle Pitts, two of the best playmakers in the country.

Georgia, defensively, should be up for it despite some absences. The Bulldogs allowed 42 points to Alabama in their lone defeat. The other four games? A combined 40 points. Can Georgia keep up offensively? That is a major question. I’m feeling points here (aka the Over).

BYU (-3.5, 61.5) at Boise State: This game will be played on Friday night. It’ll start just before 10 p.m. ET, which means you should caffeinate accordingly. It’ll be worth it, and there might not be a better game played on a Friday evening all year.

Perhaps more interesting than the matchup is the line movement. Boise State opened Sunday as a two-point favorite. The line quickly moved five points in a few hours and has settled at a field goal. Since returning to action, Boise State is 2-0 straight up and against the spread. BYU, now a dark-horse playoff team, has covered the number in five of seven games. If you haven’t seen BYU quarterback Zach Wilson play yet, this is appointment viewing.

Michigan (-3, 54.5) at Indiana: At this point, it’s hard to rate Jim Harbaugh’s worst losses. The competition is fierce, and the list is expanding. Losing as a three-touchdown favorite to a rival that just lost to Rutgers, one of the conference’s bottom dwellers, has to be up there. And yet the Wolverines will be the chalk.

Indiana has won and covered both games, but the Hoosiers are still home underdogs despite being ranked in the top 15. Before last week’s game, it felt right to finally feel confident in Michigan. The Wolverines responded with, well, you probably saw. That said, I’m tempted to do it again. Wolverines win. Wolverines cover. This column will self-destruct if these things don’t happen.

Oklahoma State (-12.5, 45.5) at Kansas State: A week ago, both Big 12 schools were thriving with just one loss between them. Then Oklahoma State fell in a thriller to Texas. Then Kansas State went to Morgantown and caught on fire, as things in Morgantown often do, against West Virginia.

One thing is clear about this matchup: Bettors don’t expect to see an abundance of points. The total opened at 52.5 and has nearly come down a touchdown. There is offensive talent in this game, although it’s largely on Oklahoma State’s side. Chuba Hubbard at running back. Spencer Sanders at quarterback. Tylan Wallace at wide receiver. The Wildcats, after really struggling offensively last week, might struggle to keep up. They’ll have to channel their effort against Oklahoma from earlier this season. If not, Pokes might roll.