Four Russian nationals and a Ukrainian have been charged with running a sophisticated hacking organization that penetrated computer networks of more than a dozen major American and international corporations over seven years, stealing and selling at least 160 million credit and debit card numbers, resulting in losses of hundreds of millions of dollars.

Indictments were announced yesterday in Newark, where US Attorney Paul Fishman called the case the largest hacking and data breach scheme ever prosecuted in the US.

Princeton-based Heartland Payment Systems, which processes credit and debit cards for small to mid-sized businesses, was identified as taking the biggest hit in a scheme starting in 2007 — the theft of more than 130 million card numbers at a loss of about $200 million.

Atlanta-based Global Payment Systems, another major payment processing company, had nearly 1 million card numbers stolen, with losses of nearly $93 million, prosecutors said.

The indictment did not put a loss figure on the thefts at some other major corporations.