“Pharma bro” scammer Martin Shkreli returned to Brooklyn federal court Monday to face an additional securities fraud charge related to his alleged $11 million Ponzi scheme.

“Not guilty,” Shkreli told Judge Kiyo Matsumoto with a smile when she asked him how he wanted to plead to the new charge.

He and his co-defendant, Evan Greebel, a lawyer, were charged in a superseding indictment filed last week with conspiracy to commit securities fraud.

Shkreli was dubbed the “most hated man in America” after jacking up the price to life-saving medication Daraprim by 5,000 percent.

Feds have charged him and Greebel in an unrelated scheme in which Shkreli allegedly skimmed money from his biopharmaceutical firm Retrophin in order to pay off debts from two failing hedge funds.

Shkreli’s lawyer Benjamin Brafman said the newest charge doesn’t add anything “of value” to prosecutors’ “flawed theory.”

Greebel, a lawyer for Retrophin, also pleaded not guilty Monday.

Both men will return to court July 14 when a trial date is expected to be set.

Here’s a look back at some of Shkreli’s most loathsome moments: