Wells Fargo & Co., the largest US home lender, will no longer enroll customers in debit-card rewards programs.

“Due to pending regulatory changes that are expected to result in a significant reduction in fees retailers pay issuers for debit-card transactions, Wells Fargo will no longer be enrolling customers in the debit-card rewards programs,” Lisa Westermann, a spokeswoman at the San Francisco-based bank, said in an e-mail.

The change includes both stand-alone programs and those where customers combine their debit and credit card into a single program, Westermann wrote. Customers already enrolled in the program and credit-card holders will not be affected, she said.