MOTHER of three Demi Moore is not taking her big-screen comeback lightly.

Pictures from the set of “Charlie’s Angels 2: Full Throttle,” in which the 40-year-old actress plays a villainous fallen Angel named Madison Lee, show the va-va-va-voom results of a reported full body makeover.

Moore’s once-stellar career has taken a nose dive since her last high-profile outing, in the 1997 flop “G.I. Jane” (best not even speak of the 2000 mega-bomb, “Passion of Mind”).

So she hasn’t left anything to chance (or Mother Nature) for her role in the sequel to the blockbuster adaptation of the cheesy TV series (for which the former $10 million-a-picture actress reportedly took a huge salary cut).

The star hired a nutritionist, a trainer, a yoga instructor and a kickboxing coach to supplement a reported $380,000 worth of cosmetic surgery, including an operation to downsize her breast implants; liposuction on her stomach, buttocks and thighs; collagen for her lips; and porcelain caps for her teeth.