SOME stars make a career playing dweebs. Here are some of Hollywood’s leading losers:

JASON BIGGS

A single performance as the protagonist in last year’s teen sex comedy “American Pie,” crowned Biggs the new king of klutz. Wincing his way through a series of painfully embarrassing attempts to lose his virginity, he managed to be charming and likable. He played a similar role as Freddie Prinze Jr’s inept, sex-obsessed roommate in this year’s “Boys and Girls,” and plays the lead in Amy Heckerling’s “Loser” – say no more.

JOHN CUSACK

The thinking woman’s heartthrob has made pining after girls in the rain into an art form. The former Brat Packer played tormented twerps in 1984’s “Sixteen Candles,” 1985’s “Better Off Dead” and 1989’s “Say Anything.” He revisited his outcast past in 1999 as the grungey puppeteer in “Being John Malkovich,” and again this year as an immature, music-obsessed thirtysomething in “High Fidelity.”

ADAM SANDLER

Sandler joined Hollywood’s $20 million-a-picture club by being a nincompoop. The “Saturday Night Live” alum won moviegoers’ hearts – and got the girl – playing mumbling misfits in two 1998 films: “The Wedding Singer” and “The Waterboy.” He continued his reign as cinema’s most lovable slacker in last year’s “Big Daddy” and seems poised to become this millennium’s Jerry Lewis.

BEN STILLER

The diminutive actor inhabited one of the all-time classic loser roles, fumbling his way through the 1998 comedy smash “There’s Something About Mary.”

As a bashful high-school misfit trying to woo blond goddess Mary (Cameron Diaz), he got his private parts caught in his tux zipper, wrestled with an amphetamine-fueled pooch, and was responsible for Mary’s infamously inappropriate hair gel. Along the way, he created one of the most endearing blockheads in cinematic history.