DID the real-life romantic relationships of the “America’s Sweethearts” stars succumb to some sort of curse on this romantic comedy about an estranged Hollywood couple?

Roberts’ recent high-profile phffft with longtime boyfriend Benjamin Bratt wasn’t the only casualty.

While the movie was shooting, Hank Azaria – who plays a Spanish actor who breaks up John Cusack’s marriage to Catherine-Zeta Jones – split from his real-life wife, Helen Hunt.

Meanwhile, Cusack seems to be on the outs with his girlfriend, Neve Campbell. Page Six reported recently that he was seen canoodling with Shoshanna Lonstein, Jerry Seinfeld’s ex.

No word – yet – on whether the honeymoon’s over for Zeta-Jones and hubby Michael Douglas. The couple recently had a son.