Katie Couric will interview US Secretary of State Hillary Clinton in her final broadcast as anchor of the CBS “Evening News” Thursday.

Couric, 54, will ask Clinton about President Barack Obama’s speech at the State Department on the recent upheaval in the Arab world.

Thursday’s show will also include a collection of Couric’s “big moments as anchor over the past 5 years,” she tweeted to fans, adding she had a “strange feeling” preparing for her final broadcast.

Couric gained national attention when she became co-host of NBC’s “Today” show in 1991. She left the morning show in 2006 to join CBS.

Longtime “60 Minutes” correspondent Scott Pelley, 53, will replace Couric in the anchor’s chair as she reportedly pursues a deal with ABC for a syndicated talk show.