MIKE Tyson is ready to take a bite out of Jimmy Kimmel.

The unpredictable former heavyweight boxing champ has agreed to be the co-host on Kimmel’s live late night show the week of March 31.

Kimmel’s other guests that week will include Wanda Sykes, Shannen Doherty, baseball great Tommy Lasorda and Ali Landry.

Kimmel’s show – which has been crushing late night rival Craig Kilborn in the ratings with men 18 to 49 years old – airs live five nights a week.

Each week since its debut after the Super Bowl in January has featured a guest host, including rapper Snoop Dogg, boxing promoter Don King, future Friar’s Club honcho Jeffery Ross and Kimmel’s current girlfriend/comic, Sarah Silverman.