Plenty of activity afoot this season on off-Broadway – and there’s no doubt about its most eagerly anticipated production: “Road Show,” the first new musical by Stephen Sondheim since his 1994 “Passion.”

The show, co-written by John Weidman, is about two brothers seeking fame and fortune in the early part of the century. It was first presented in 1999 as a workshop production called “Wise Guys.”

Later renamed “Bounce,” it was seen in Chicago and Washington, DC, in 2003, but mixed reviews scuttled its New York plans.

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It finally arrives here, with yet another title change. Now called “Road Show,” it begins performances at the Public Theater on Oct. 28 in a rewritten version starring Michael Cerveris and Alexander Gemignani and staged by John Doyle, the British director responsible for the acclaimed revivals of “Sweeney Todd” and “Company.”

Let’s hope the long, long wait has been worth it.

There are several other shows that offer strong possibilities.

“Romantic Poetry” (Manhattan Theatre Club, Sept. 30) is a new musical collaboration between John Patrick Shanley, the author of “Moonstruck” and the Tony- and Pulitzer-winning “Doubt,” and Henry Krieger, the composer of “Dreamgirls.” “Mindgame” (Soho Playhouse, Oct. 28), a thriller about a jailhouse encounter between an author and a serial killer, stars Keith Carradine

and marks the New York stage debut of filmmaker Ken Russell (“Women in Love,” “Tommy”).

Nicky Silver’s latest play “Three Changes” (Playwrights Horizons, now previewing) offers Dylan McDermott

(“The Practice”), Maura Tierney (“ER”) and Scott Cohen (“NYPD Blue,” “Gilmore Girls”) in a dark comedy about a married couple whose lives are thrown into turmoil by the arrival of the husband’s wayward brother.

The Roundabout

presents a timely revival

of David Rabe’s award-winning drama “Streamers” (Laura Pels Theatre, Oct. 17), about four young soldiers waiting to be shipped off to Vietnam.

“Farragut North”

(Linda Gross Theater, Oct. 22), a political drama about a press secretary who becomes embroiled in a scandal, is now receiving its world premiere courtesy of the Atlantic Theatre Company.

And Frank Pugliese’s “The Talk” (Cherry Lane Theater, Sept. 9), starring Bobby Cannavale and Titus Welliver as two of four brothers reuniting

for their mother’s

funeral, marks a

welcome return for

the too-long- dormant Naked Angels theater company.