The entertainment industry — and beyond — was left reeling after legendary director Rob Reiner and his wife were found stabbed to death in their Hollywood home, with tributes pouring in as soon as the tragic news spread.

Reiner, 78, a beloved Hollywood icon known for his hit films like “The Princess Bride,” “When Harry Met Sally” and “This is Spinal Tap,” was found dead alongside his 68-year-old wife, Michele, at their Brentwood mansion on Sunday afternoon.

The couple’s son Nick, 32, has been taken into custody and charged with the murders. He’s being held on a $4 million bail.

Actors, directors and others who worked with or were influenced by the “All in the Family” star have publicly reacted to his tragic death.

Ben Stiller tweeted, “What a huge loss. Rob Reiner was one of my favorite directors. He made some of the most formative movies for my generation. He came out form behind a huge comedic shadow of the great Carl Reiner and being a tv actor to being a a great director who made an incredible run of movies. Spinal Tap is one of the best comedies ever made – and the list goes on. He was a kind caring person who was really really funny. I didn’t know him well but was always a fan and I feel a real sadness for those who did, and his family.”

Jerry O’Connell, who starred in Reiner’s 1986 film “Stand By Me,” told People, “We’re all shocked. I can’t speak for them [costars Wil Wheaton and Corey Feldman], but for myself, I feel like a parent has passed, you know? I just feel like a parent has passed.” 

O’Connell called the news “really devastating,” adding, “Everything I have in my life is because of Rob Reiner. Everything I have, my children, my wife, my, just everything.” 

Kiefer Sutherland, who also starred in “Stand By Me,” said in a statement, “Like so many, my heart was broken today when I heard the news about Rob Reiner and his wonderful wife, Michele. Rob was one of the kindest gentleman I’ve ever had the pleasure of working with, when I was very young he gave me an opportunity that changed my life, and I will forever be grateful.”

 “Princess Bride” star Cary Elwes posted a picture of their chairs from the set, with the caption, “No words…”

Kathy Bates, who starred in Reiner’s 1990 film “Misery” which won her an Oscar, told The Post, “I’m horrified hearing this terrible news. Absolutely devastated.”

“I loved Rob. He was brilliant and kind, a man who made films of every genre to challenge himself as an artist. He also fought courageously for his political beliefs. He changed the course of my life. Michelle was a gifted photographer. She shot my beautiful photos for the Misery campaign. My heart breaks for them both. My thoughts are with their family,” the “Matlock” star added.

Paul McCartney wrote on Instagram, “What a tragedy the death of Rob Reiner and his wife, Michele, is. It is so shocking in many ways but for me especially so, because over the last year I had been working with him. He directed me in ‘Spinal Tap II: The End Continues’. He was such an upbeat, lovable man. Life can be so unfair and this tragedy proves it. His father, Carl Reiner, was a great humourist before him and Rob followed in his dad’s footsteps doing a terrific job making many great films. I will always have fond memories of Rob and the idea that he and his wife will no longer be in the world with us is heartbreaking. Thanks for all the humour, Rob. Rest in Peace.”

Fellow director Ron Howard tweeted about Reiner, “Our careers and lives intersected often over the decades from Rob writing the pilot script for Happy Days and then as we each shifted from acting careers into directing and producing. He proved to be a superlative filmmaker, a supportive colleague and at all times a dedicated citizen. Rob will be missed on so many levels. My heart goes out to his family and his many close friends.”

Jamie Lee Curtis, whose husband Christopher Guest starred in “This Is Spinal Tap,” said on behalf of the couple, “Christopher and I are numb and sad and shocked about the violent, tragic deaths of our dear friends Rob and Michele Singer Reiner and our ONLY focus and care right now is for their children and immediate families and we will offer all support possible to help them.”

“There will be plenty of time later to discuss the creative lives we shared and the great political and social impact they both had on the entertainment industry, early childhood development, the fight for gay marriage and their global care for a world in crisis,” Curtis continued. “We have lost great friends. Please give us time to grieve.”

“Horrified to hear of the passing of Rob Reiner and his wonderful wife Michelle (sic). So much love to their kids and family,” Elijah Wood posted on X in the wake of the shocking news.

“Horrible. I didn’t think the day could get worse,” “Two and a Half Men” star Jon Cryer wrote on Threads.

“Richard Jewell” star Paul Walter Hauser wrote in a lengthy, heartfelt Instagram post crediting Reiner’s movie “A Few Good Men” as the reason he became an actor.

“Grieving the loss of my favorite director of all-time,” Hauser wrote. “A Few Good Men is THE reason I became an actor, and Rob’s filmography behind the camera is THE reason I wanted to direct and still do.”

Actor Josh Gad called Reiner “one of the greatest directors of our time” in a touching post paying tribute to the legendary filmmaker and his wife.

“Rob Reiner and his wife Michelle (sic) were two of the most kind and caring souls you could ever imagine. He cared so much for those who had no voices,” the “Frozen” actor wrote.

“This loss is devastating. I cannot express how much this hurts. Love you Rob and Michelle. Thank you for all you gave us.”

Actress Virginia Madsen, who starred in Reiner’s 2012 film “The Magic of Belle Isle,” thanked him “for giving us so much joy to hold on to.”

“Life and talent always turned up to 11,” Madsen wrote, in reference to his cult classic film “This Is Spinal Tap.”

Outside of Hollywood, former President Barack Obama said the Reiners “lived lives defined by purpose.”

“Michelle and I are heartbroken by the tragic passing of Rob Reiner and his beloved wife, Michele. Rob’s achievements in film and television gave us some of our most cherished stories on screen,” he wrote on X.

“But beneath all of the stories he produced was a deep belief in the goodness of people—and a lifelong commitment to putting that belief into action. Together, he and his wife lived lives defined by purpose. They will be remembered for the values they championed and the countless people they inspired. We send our deepest condolences to all who loved them.

Former Speaker of the House Nancy Pelosi said she was devastated by the news of the couple’s murder.

“It’s hard to think of anyone more remarkable and excellent in every field and endeavor they pursued. Rob was creative, funny, and beloved,” the California Democrat wrote. “And in all of their endeavors, Michelle (sic) was his indispensable partner, intellectual resource, and loving wife. Paul and I and our entire family mourn the loss of our very dear friends and are praying for their loved ones during an unimaginable time of grief,” she added.

“Jen and I are heartbroken by the tragic loss of Rob Reiner and Michele Singer Reiner,” Gov. Gavin Newsom posted on X.

“Rob will be remembered for his remarkable filmography and for his extraordinary contribution to humanity,” Newsom added.

Police were called to the Hollywood icon’s home on Sunday afternoon, where they discovered the longtime couple, who married in 1989, dead from stab wounds.

Their bodies were initially found by their 28-year-old daughter, Romy.

The couple’s son Nick, who has a history of addiction, was taken into custody Sunday night for allegedly murdering his parents.