The second European property (after Amsterdam’s Conservatorium) from the ascendant Set Hotels group, Hotel Café Royal is located smack-dab in the heart of London.

It overlooks Piccadilly Circus and is a short stroll from SoHo, Mayfair and the West End theater district.

Fronted by an Edwardian-era neoclassical facade, Hotel Café Royal is replete with art deco fireplaces, stained glass and fancy French-style imperial detailing.

Over the course of a century and a half — since its original debut in 1865 — everyone from Oscar Wilde to Mick Jagger to Elizabeth Taylor called the original Café Royal their home away from home. Today, the property has been meticulously overhauled by swanky British architect David Chipperfield, who’s imbued this Regent Street landmark with a luxurious-yet-restrained aesthetic ideal for discreet jet-setters.

The Akasha Holistic Wellbeing Center is a sprawling, 13,000-square-foot spa set deep underground. Anchored around the four elements — earth, water, air and fire — Akasha offers a range of Asian-inspired massages and body treatments, a massive gym, a steamy hamman (with body scrubs) and a dreamy 60-foot-long swimming pool.

Behind a historic exterior, the hotel is all new inside. Indeed, most of its 160 rooms and suites were rebuilt during the structure’s overhaul and feature Chipperfield’s signature pared-down aesthetic — rich stone baths, English oak paneling and lots of creamy Carrara marble. Prim and proper butler service aside, the rooms’ real appeal is their prime views down shopping mecca Regent Street and the bright lights of Piccadilly.

The Oscar Wilde Bar, the hotel’s former (and beloved) Grill Room, which has been renamed after its most famous guest. A riot of rococo plaster, oversized ballroom mirrors and wildly painted ceiling panels, the bar delivers both top-shelf Laurent Perrier champagne as well as seriously sumptuous (and colorful) afternoon teas complete with 20 different brews. Crave something stronger? A tipple of absinthe at the Green Bar evokes the hotel’s age-old bohemian spirit.

In a city that practically invented five-star service, Hotel Café Royal easily holds it own. But traditionalists may scoff at the property’s spare interiors — along with its occasionally over-complicated in-room electronics system.

From $540; HotelCafeRoyal.com