Rodale has picked a new Runner’s World editor-in-chief — Betty Wong Ortiz, the former editor-in-chief of Fitness, formerly published by Meredith.

Ortiz becomes the first woman to hold the top job at Runner’s World — prompting speculation that the title will be getting more in touch with its feminine side.

Ortiz succeeds David Willey, who is stepping down later this month after 14 years on the job.

Bart Yasso, a veteran dubbed the Mayor of Running — and the magazine’s chief running officer — earlier this year said he would retire in 2017 after a 30-year gig at Runner’s World.

At the end of 2015, Rodale shut down its hard-core long-distance title Running Times effective with the January/February 2016 issue.

Rodale is likely to face new competition for the hearts and minds of women runners. Former Lonely Planet Managing Editor Rebecca Warren was recently tapped to succeed Jessica Sebor as editor-in-chief of Women’s Running, published by the smaller Competitor Group Inc.

It comes at a time when women are embracing running like never before. According to Running USA, of the 17 million race finishers in the US last year, 57 percent were female.