“Today” star Savannah Guthrie issued a plea for prayers in a heartfelt Instagram post as the desperate search for her missing 84-year-old mom nears its 48-hour mark.

Nancy Guthrie is feared to have been snatched from her bed in her million-dollar Catalina Hills home after returning from dinner on Saturday night — and her disappearance is being treated as a crime.

Search dog teams, drones and volunteers searched the home but cops revealed some “concerning” items had been found.

Follow The Post’s live updates on Savannah Guthrie’s missing mom

In an Instagram post on Monday night, Savannah said she believes in prayer and in God.

“We believe in prayer. We believe in voices raised in unison, in love, in hope. We believe in goodness,” she wrote.

“We believe in humanity. Above all, we believe in Him,” she wrote along with a photo that reads, “Please pray.”

“Thank you for lifting your prayers with ours for our beloved mom, our dearest Nancy, a woman of deep conviction, a good and faithful servant.

“Raise your prayers with us and believe with us that she will be lifted by them in this very moment. We need you,” the post continued.

The journalist, who previously described her mom as “God’s first, best and most important gift” to her, ended her plea with three words: “Bring her home.”

Nancy reportedly enjoyed dinner with Savannah’s sister, Annie, on Jan 31 and didn’t really show any “red flags,” according to a US Weekly report.

Nancy is “sharp as a tack,” according to Chris Nanos, the Pima County Sheriff, but she cannot walk 50 yards on her own and is dependent on life-saving meds.

Cops previously warned that 24 hours without the medication could be fatal for her.

Her cell phone, car, and wallet were left behind at the home and DNA was recovered at the scene – which has been sent to a Phoenix lab, as reported by KPNX.

Cops have urged Nancy’s neighbors to review any surveillance footage that may help the case.