Bartolo Colon, who turned 43 on Tuesday, had an interesting exchange with a fan the previous night, according to a witness.

The fan was heckling Colon, who pitched seven innings of one-run ball in Monday’s 7-1 win, about having two families. The Post reported last week he has children with two different women and is being sued by one of them for child support.

Colon, according to the witness, deflected the barb by telling the heckler he actually has three families.