Robinson Cano homered twice and hit one of three straight long balls off an ineffective Johan Santana to lead the Yankees to a 9-1 rout of the Mets on Friday night.

Hiroki Kuroda allowed one hit in seven scoreless innings before leaving with a bruised left foot. Cano ended Santana’s bid for a second straight no-hitter with a two-run shot in the second, then connected again in the third to begin a string of three consecutive home runs by the Yankees.

In the first Subway Series matchup of the season, Kuroda (5-6) gave up only a two-out double in the sixth to Omar Quintanilla.

Santana (3-3) was given two extra days of rest after throwing a career-high 134 pitches last Friday against St. Louis in the first no-hitter in Mets history.