There will be bittersweet memories associated with Anthony Volpe’s first career home run. 

The young shortstop came through for his most memorable moment of the season on a Friday night the Yankees otherwise would prefer not remembering. 

Clay Holmes flushed a one-run lead in the eighth inning, spoiling an evening that had seemed destined to belong to Volpe, but ended in a 4-3 loss to the Twins in front of 41,039 in The Bronx. 

In the decisive eighth, Holmes was summoned an inning earlier than usual because the top of Minnesota’s lineup, which was righty-heavy, was coming up. 

Michael A. Taylor poked a leadoff single to right before Holmes lost a battle with Byron Buxton, who drew a walk.

That set the table for the most booed player of the series. 

Carlos Correa, the hated former Astros star who already had homered two innings prior (and Thursday night), drilled a two-run double down the right-field line to steal the lead. 

“It stayed up,” Holmes said of his 1-2 sinker. 

“Probably not his best two-strike pitch there,” manager Aaron Boone said of Holmes, who had gotten ahead 1-2 on Taylor, Buxton and Correa, but could not finish them off. 

Three of Minnesota’s four runs were driven in by Correa, who is playing for the Twins because he failed physicals with the Mets and Giants this offseason. 

The Yankees went quietly in the eighth and ninth innings, not getting a runner into scoring position and dampening a night that had begun with such promise and noise. 

Volpe, leading off in a lineup that lacked DJ LeMahieu, connected for his first career dinger on the second pitch he faced. 

The first victim of the shortstop’s career was righty Louie Varland, who dotted the top of the strike zone with a 95.3-mph four-seam fastball, a pitch and location against which Volpe had struggled in the first few weeks as a major leaguer.

This time, the 21-year-old jumped on the ball and reversed it 394 feet to left-center, clearing the fence and igniting a crowd that quickly has welcomed its shortstop of the present and future. 

The fans will remember watching him round the bases for the first time. Volpe will not. 

“I was completely blacked out,” Volpe said with a smile. 

Aaron Judge, the No. 2 hitter, used the only timeout of his at-bat before it began to allow for a few extra seconds of applause directed Volpe’s way. 

Then, the home run champion stole the attention right back, blasting his own solo homer to right-center and putting the Twins in a 2-0 hole three pitches into Varland’s outing. 

In his 14th major league game, Volpe showed more signs that his bat is beginning to adjust to the elevated competition.

Volpe, who also walked and struck out twice, has a modest three-game hitting streak that has upped his average from .129 to .171. 

“I feel like I’m making adjustments,” Volpe said, “and I feel like the results will take care of themselves.” 

His homer was wasted, however, as the Yankees (8-6), who have not lost a series this year, have dropped the first two games of a four-game set. 

The Yankees were rolling until the sixth, when Correa homered to the short porch in right to bring the Twins within 2-1. 

In the bottom of the inning, Giancarlo Stanton knocked his fourth homer of the season, a solo shot, to retake the two-run cushion. 

But Kyle Garlick hit a solo homer of his own against Nestor Cortes in the seventh, which brought Minnesota within striking distance — and set up Correa to strike. 

Cortes was solid through seven innings, in which he gave up two runs on five hits and struck out seven. 

The lefty has allowed two runs or fewer in nine straight starts since Oct. 21, 2022, matching the longest such streak by a Yankees starting pitcher in club history.

Luis Severino (from 2018-22), Michael Pineda (in 2014) and Art Ditmar (in 1959) also have recorded nine straight such starts. 

“The big question for me from everybody else has been: Can he continue to do it?” Cortes said. “So I’m out there proving myself that I can.” 

As is Volpe, which made Holmes feel all the worse. 

“Definitely disappointing,” Holmes said after his first blown save of the season. “Frustrating.”