In their first game back after an unscheduled five-day layoff, the Yankees looked like they hadn’t learned their break was over in a 5-1 seven-inning loss to the Braves to open Wednesday’s doubleheader in Atlanta.

The defeat extended their losing streak to four games and ended Gerrit Cole’s winning streak at 20.

The Yankees had been sidelined since falling to the Rays in The Bronx on Thursday, as the postponement of the Subway Series due to two COVID-19 cases with the Mets cost them three games and Tuesday’s scheduled game at Truist Park in Atlanta was rained out.

Their return to the field was ugly from beginning to end in the opener, as Cole allowed three homers, and the Yankees had little answer for Atlanta right-hander Ian Anderson, who took a no-hitter into the sixth in his MLB debut.

The 22-year-old retired the first eight batters he faced until Tyler Wade drew a walk with two outs in the third. Wade swiped second, but was stranded there when Mike Tauchman grounded out to end the inning.

The Yankees didn’t get their first hit until Luke Voit’s homer to the opposite field with one out in the sixth. It was the fifth straight game Voit had homered and cut the Yankees’ deficit to 4-1.

By then, Cole had already given up three home runs.

The first came on Cole’s first batter of the game, as Ronald Acuna, Jr. hit a 473-foot shot into the left-field seats to give Atlanta a 1-0 lead.

Cole walked Acuna with one out in the third and Dansby Swanson followed with an opposite-field two-run homer to make it 3-0.

Later in the third, Marcell Ozuna went deep, this one another solo shot that traveled an estimated 469 feet as the Braves extended their lead to 4-0.

“I just would have liked to have pitched better,’’ said Cole, who allowed five runs in five-plus innings. “It just seemed to be a little bit feast or famine. I had good command for a period of time [and] then some bad command in bad spots. … We just didn’t match up and they stayed one step ahead of me too many times.”

The Yankees threatened without a hit in the fourth. Voit reached on an error by third baseman Austin Riley to open the inning. Aaron Hicks grounded into a force out and Mike Ford walked to bring up Gio Urshela, but Urshela hit into a double play.

Gary Sanchez drilled a ball to third to start the fifth, but Riley made a diving play to rob the catcher. Anderson hit Estrada with a pitch with two outs before Wade struck out to end the inning.

Cole was pulled after allowing the first two batters to reach in the bottom of the sixth. The right-hander was at 103 pitches and displayed none of the anger he showed when Aaron Boone removed him in the seventh inning of his previous outing.

Luis Cessa immediately gave up a run-scoring double to Nick Markakis before he retired the next three batters.

It was Cole’s first regular-season loss since May 22 of last year, when he was with the Astros. In that span, Cole was 20-0 with a 1.97 ERA, covering 28 starts.

But on Wednesday, he was no match for the Braves or Anderson.