In search of an extra bullpen arm, the Yankees designated Colten Brewer for assignment Friday and called up Greg Weissert from Triple-A Scranton/Wilkes-Barre.

Brewer had allowed just one hit in five scoreless innings before a poor (and lengthy) outing Thursday. The 30-year-old, who had been picked up at the start of the season in a trade with the Rays, pitched 3 ¹/₃ innings, in which he allowed four runs, in relief of Jhony Brito.

The Yankees needed a fresh arm after Brewer was taxed and Ian Hamilton pitched three innings, so they burned Brewer, who is out of minor league options, to bring up Weissert.

Such is the state of the Yankees’ bullpen, which seems to cycle through quality arm after quality arm and entered their game against the Twins on Friday with the second-best ERA in baseball.

The Yankees have been without Lou Trivino, Scott Effross, Tommy Kahnle and, for the past week, Jonathan Loaisiga due to various injuries. Despite that, the bullpen’s collective ERA (2.24) was second to only the Brewers’ (1.65) — before Clay Holmes allowed two runs in the eighth inning of a 4-3 loss the Twins in The Bronx.

“I think overall the group’s done a really nice job, especially with some key figures down,” manager Aaron Boone said.

Weissert, a Bay Shore native who debuted last season and had allowed one run in 5 ¹/₃ Triple-A innings this season, represents one more intriguing arm alongside Holmes, Wandy Peralta, Michael King, Ron Marinaccio, Albert Abreu, Jimmy Cordero and Hamilton.

“We got a nasty pen — the whole team, we’re good,” said Hamilton, who has allowed two runs in 8 ²/₃ innings.

“We’re super deep, I think, in the organization,” Marinaccio said. “You see Weissert comes up today … and there’s plenty more behind him down there. And then obviously we have a couple bigger names on the IL that’ll be coming back.

“The organization has built such great depth here.”

DJ LeMahieu (quad) did not play for a third straight game, but he believed he would return Saturday. He was on deck to pinch-hit for Isiah Kiner-Falefa in the ninth inning before Willie Calhoun’s flyout ended the game.

“I think I’ll be full-go tomorrow,” LeMahieu said, sounding more confident than his manager.

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“We’ll see,” Boone said when asked whether LeMahieu would start Saturday. “Hopefully.”

LeMahieu, who said he was rounding first base in Cleveland on Tuesday when he felt the quad tighten, has been running without issue, he said.

Kahnle (right biceps tendinitis) threw from 60 feet Friday and is awaiting his next step of throwing from a mound.

The righty said he has not had a setback, despite the Yankees last week moving him from the 15-day injured list to the 60-day IL. He will not be eligible to return until late May.

“It makes sense,” said Kahnle, who said he previously was shut down from throwing for about four weeks.

Kahnle said he is now pain free, but unsure when a rehab assignment would come.

Luis Severino (right lat strain) threw a bullpen session Thursday that “went well,” Boone said. His next step will be a bullpen session in which he throws two “innings.”

Carlos Rodon (left forearm strain) threw Friday and is “ready to take off a little bit,” Boone said.

The lefty threw on a slope and will throw a two-up bullpen session Sunday or Monday. Boone did not know how many rehab starts he would need before debuting.