Jose Quintana’s Mets debut was acceptable, but the rest of Thursday afternoon provided more angst than excitement for the home team.

There was the frustration of an important offensive player, Tommy Pham, leaving the game with an apparent injury.

But the Mets also didn’t hit enough or get a middle-inning relief pickup as needed, and a Pete Alonso error heavily contributed to their 6-2 loss to the White Sox at Citi Field.

The Mets, left unfulfilled in their quest for a series sweep, had a three-game winning streak snapped and finished 3-3 on their homestand — at a time treading water isn’t sufficient.

The Mets (45-51) have nine games scheduled before the Aug. 1 trade deadline and certainly haven’t shown enough tho suggest they should be anything but sellers.

Pham, who began the day with a .976 OPS since May 28 — the fifth highest in the National League over that stretch — left the game with tightness in his right groin after barely running to first base on a double-play grounder in the third inning.

Pham will undergo imaging before the Mets open their series in Boston on Friday and a determination will be made on his status.

“Buck [Showalter] is just looking out for my best interests because I probably would have been dumb enough and tried to play through this and probably would have made it worse,” Pham said of coming out of the game. “Buck is such a great guy and he’s just looking out for my well-being.”

Pham had tightness in the groin that forced him to leave a game against the Padres on July 9, but he returned immediately after the All-Star break.

“It doesn’t feel as bad as San Diego, but there is some tightness,” Pham said.

Quintana, in his Mets debut following rib surgery that had kept him sidelined since spring training, allowed two earned runs on six hits with three strikeouts, and departed after 77 pitches.

The left-hander retired eight of the final nine batters he faced and left with the Mets behind 2-1.

The White Sox took control against Drew Smith in the sixth inning by scoring four runs, only one of which was earned, on three hits, an error and a walk.

The right-hander recorded just two outs before departing to a smattering of boos.

Alonso misplayed Luis Robert Jr.’s grounder for an error to begin the inning before Eloy Jimenez singled and Jake Burger walked to load the bases.

Yasmani Grandal followed with a hard fly ball to right. Jeff McNeil started in on it, but the ball landed on the warning track for a two-run double that gave the White Sox a 4-1 lead.

Oscar Colas’ sacrifice fly brought in another run and Elvis Andrus’ RBI triple put the Mets in a 6-1 hole.

“Just overall I haven’t played well,” said Alonso, who entered with a .558 OPS in July. “It’s not fun not playing well.”

As for Robert’s grounder, which he booted in the first-base hole, Alonso said the ball had a difficult spin.

“I didn’t know whether to charge it or not charge it and eventually as an infielder you have to make a decision to retreat or go bet the ball,” Alonso said. “I did neither and it ate me up and that is what caused the error. I totally misjudged the spin of the ball.”

Quintana pitched to soft contact in the first inning, allowing one run on three straight singles.

Jimenez delivered an RBI single that gave the White Sox a 1-0 lead.

Quintana stranded runners on second and third by striking out Grandal to conclude the inning.

Zach Remillard doubled leading off the second and Andrus’ sacrifice fly put the Mets in a 2-0 hole. But the White Sox were finished threatening against Quintana.

In the third, Jimenez hit into a double play to help kill an inning. Remillard singled in the fourth and was left stranded before Quintana retired the side in order in the fifth.

“I think every inning I felt better and better,” said Quintana, who joined the Mets on a two-year contract worth $26 million. “I did worry a little with the [pitch] clock, but it was good. A couple of weak contacts that I could do nothing about, but I think overall it was great.”

Omar Narvaez singled in the third inning against Michael Kopech and Brandon Nimmo walked before Pham hit a grounder that left his bat at 109.4 mph.

The ball was snagged on a hop by shortstop Tim Anderson, who started an inning-ending double play.

Pham was replaced in left field for the start of the fourth inning.

Narvaez’s solo homer, his first in a Mets uniform, with two outs in the fifth cut the deficit to 2-1. Narvaez started behind the plate to give Francisco Alvarez, who was DH, a rest following a night game.

Alonso hit an RBI single in the eighth after Nimmo’s leadoff double.

“We won a series, that is what’s important,” Pham said. “[Quintana] went out there in his first game and there’s a lot of positives in how he pitched today.”