It’s probably best that Mickey Callaway learned in his 15th game as a manager the harshest of all lessons that eventually visit all major league managers, rookie or veteran, lessons that have been handed down since Connie Mack and John McGraw were wide-eyed kids.

It goes something like this:

You can study every number that matters …

… and you can be as prepared as any man alive …

… and you can have every situation accounted for …

… and you can make every move that should be made according to the situation of a game …

… and it still might not matter, if your ballplayers aren’t going to play ball with the effectiveness and the crispness and the sharpness for which they are handsomely paid.

“That’s always been the case,” Callaway said on The Day After, a day in which a certain element of vocal Mets fan became completely unhinged and unburdened themselves on talk radio and social media, the only way they could handle the come-from-ahead 8-6 loss the Nats slapped on the Mets Monday night.

“If you have good players you’re going to be good. It’s never about what I do that helps us win games, it’s what the players do. Look, we have a great bullpen that’s been tremendous. It’s just that things didn’t work out [Monday] night.”

That may be at the root of all the frustration that was unleashed by Mets fans Tuesday: The one thing they couldn’t blame was the manager, and usually the manager is the key to coming to terms with bad losses. You can always, usually, blame the manager for something, even if you have to stretch a little.

But Callaway managed a perfect, if perfectly cluttered, inning.

Some questioned if he shouldn’t have let Jacob deGrom, who’d been brilliant all night, pitch to one more batter. That batter was Howie Kendrick, whom deGrom had already struck out three times.

“But it was obvious to me three pitches into the at-bat by Trea Turner [the batter before Kendrick] that Jacob was spent,” Callaway said. “It wasn’t about pitch count [103] but he wasn’t finishing his pitches like he had been earlier, wasn’t locating the ball. We hoped he could finish Turner, but Trea put a great at-bat against him.”

When Turner singled, deGrom admitted, “I knew I was coming out of the game,” with one out and two on, the Mets up 6-1, and he was fine with it. “Our bullpen is a strength of this team. I trust these guys.”

So began the almost absurd parade of incompetent:

Seth Lugo was up first. He has been terrific (though shaky his last time out, Friday against Milwaukee). He walked Kendrick on four pitches.

Callaway pulled Lugo, inserted Jerry Blevins, who is on this team specifically to face Bryce Harper. The bases were loaded, and it was still a five-run game, but you have to use Blevins here. Blevins threw a strike, then two balls, then Harper drilled a hard single through the hole to right. It was 6-3.

Callaway pulled Blevins, inserted AJ Ramos, who was acquired by the Mets last year as a “bonus closer.” The eighth inning is his purview (though it can often be an adventure). He struck out Ryan Zimmerman and said, “I felt strong and confident.” Citi Field exhaled. Then he allowed a single to Pedro Severino, reloading the bases, putting the tying run on.

Then he walked ex-Met Matt Reynolds, hitting .125. On four pitches.

“Not good,” Ramos said.

It was 6-4. The bases were still loaded. Callaway pulled Ramos, brought in Jeurys Familia, his closer, who had been nearly flawless all year. (He made it a double-switch, inserting Wilmer Flores at first for Adrian Gonzalez, which was the only thing he did that might — might — be second-guessed, as we’ll soon see.)

Familia fell behind Wilmer Difo 2-and-1, then did what he does: He induced a ground ball. Only, the ball found the skinny alley between Flores and second baseman Asdrubal Cabrera. (Would Gonzalez, a lefty, have been able to snare it? It’s a fair question … )

It was 6-6.

Familia promptly plunked Moises Sierra, who’d led the inning off with an innocent single off deGrom. Michael A. Taylor stepped up, and Familia fell behind 3-1, and it was absolutely clear what would happen next. Ball four made it 7-6.

And that was that.

“You always have to worry about what you can control,” Callaway said.

And simply shake your head at all the things you cannot.