Major League Baseball will begin cracking down on its sticky situation beginning Monday, the commissioner’s office announced in a memo sent to all 30 teams.

Pitchers will be subjected to ejections and 10-game suspensions if caught using illegal foreign substances to manipulate baseballs, the release stated, and umpires will be allowed to randomly check pitchers, even if not requested by opposing managers.

“After an extensive process of repeated warnings without effect, gathering information from current and former players and others across the sport, two months of comprehensive data collection, listening to our fans and thoughtful deliberation, I have determined that new enforcement of foreign substances is needed to level the playing field,” commissioner Rob Manfred said in the statement. “I understand there’s a history of foreign substances being used on the ball, but what we are seeing today is objectively far different, with much tackier substances being used more frequently than ever before.

“It has become clear that the use of foreign substance has generally morphed from trying to get a better grip on the ball into something else — an unfair competitive advantage that is creating a lack of action and an uneven playing field.”

Penalties will rise for repeat offenders, the statement added, with teams and other club personnel also subject to discipline if failing to comply. Pitchers will be checked as they are coming off the mound at the end of an inning or after they’ve been replaced.

Umpires also may search catchers and position players, with the pitcher usually earning the ejection if a teammate is caught with foreign substances.

Any players refusing to cooperate with an umpire’s inspection will be “presumed to be in violation of the rules,” and also subject to ejection and suspension. Banned players will not be eligible to be replaced on the team’s active roster, another potential deterrent.

MLB initially had informed teams in March that it would begin collecting balls removed from play and analyze Statcast data on spin rates to determine the extent of the problem.

Mets manager Luis Rojas said MLB executives Theo Epstein and Mike Hill detailed the changes during a conference call Tuesday with all 30 managers. He added he planned to address his players before Tuesday’s game against the Cubs.

“I don’t think it changes much from what it’s been in the past as far as the rulebook, but there’s just been a little more noise about it,” Rojas said. “Once again I’m gonna say I’m unaware of anyone here using anything. … But we do have to talk because there are some penalties.

“But for me personally, I don’t think it’s going to change much. We all saw the whole Gerrit Cole-Josh Donaldson matchup the other day.”

Donaldson had accused the Yankees’ ace and other pitchers of using foreign substances, such as Spider Tack, last week to gain an advantage. Days later, Cole fanned Donaldson twice and retired him a third time in a win over the Twins.

“I’ve never heard of Spider Tack, God as my witness, until three weeks ago,” Yankees GM Brian Cashman said Tuesday in Buffalo, where his team was facing the Blue Jays. “The game obviously is now catching up that ‘This has become too much and this has gone too far and how do we self-correct it?’

“The only way obviously to self-correct all of it is to have people I guess go dry and not use what they’ve used for generations, at the very least.”

A few pitchers around baseball were outraged about the changes, such as Rays ace Tyler Glasnow. He blamed the crackdown for his diagnosis of a partially torn UCL after being removed early from Monday’s start.

“Do it in the offseason. Give us a chance to adjust to it,” Glasnow told reporters Tuesday. “I just threw 80-something innings and you just told me I can’t use anything. I have to change everything.

“I truly believe 100 percent that’s why I got hurt. I’m frustrated MLB doesn’t understand. You can’t just tell us to use nothing. It’s crazy.”

According to Statcast data, fastball spin rates dropped from an average of as much as 2,330 revolutions per minute over the first two months of the regular season to around 2,225 on Sunday, one week after talk of a crackdown emerged from the owners’ meeting earlier this month.

League-wide batting averages rose from .236 at the end of May to .247 through June 6 after those meetings. Strikeout percentages also have dipped slightly since the pending enforcement was first reported.

Rosin bags still will be permitted, but rosin cannot be combined with sunscreen or other substances, with umpires advised to inspect rosin bags before games to ensure they meet MLB standards.

“All I care about is what the rules are and are they going to be enforced?” Cashman said. “If they are, tell us what they are, and it’s an easy way to navigate.”

— Additional reporting by Dan Martin