The Mets are on life support, and they have yet to play their 60th game of the season.

When you go 16-31 it is nearly pull-the-plug time, and that’s the Mets’ record since their mysterious 11-1 start.

Wednesday’s punchless 1-0 loss to the Orioles at Citi Field was a new low in a season of Grand Canyon lows. The Mets have scored two runs over the past 42 innings. They were swept in a two-game series by a team that came in with a 17-41 record.

The loss was their sixth straight. Mickey Callaway’s club has somehow managed to lose eight straight games at home, turning Citi Field into a house of horrors.

They fumble away simple tasks like bunting runners along. They continue to give away outs into the shift, and on defense they can’t hit the cutoff man and their range is atrocious. In those six straight losses they have scored a total of seven runs. Over the last four of those losses, they have scored two runs in 41 innings.

In those 41 innings they have collected 18 hits while striking out 37 times. It’s amazing they even have two runs to show for that kind of putrid performance.

“I think guys are pissed,’’ Callaway said. They should be.

All those rallying-cry Mets salt and pepper shakers have been tossed in the garbage. In those six losses the Mets are 1-for-24 (.042) with runners in scoring position.

And now the Yankees could flatline the Mets over the weekend at Citi Field.

Yankee fans would like nothing better than to see their pinstripe juggernaut put the Mets out of their misery.

Make no mistake, the Mets know how important these next three games are as they have lined up Jacob deGrom, Steven Matz and Noah Syndergaard for the Subway Series.

The Mets continue to waste phenomenal starting pitching. The latest starter to get “deGromed’’ was Zack Wheeler, who pitched seven scoreless innings Wednesday.

General manager Sandy Alderson is saying be patient, there is a long way to go in this season, but the Mets need to stop the bleeding now or all is lost. Yoenis Cespedes (hip) is not likely to return until Tuesday in Atlanta, so it’s on these players now.

Todd Frazier, who just returned to the lineup Tuesday from a hamstring injury, is prepared to draw a line in the sand against his old team, the Yankees.

“Without a doubt,’’ Frazier told The Post. “We’re not panicking, but this is a place we have to get out of and we have to find a way to get out of it. If I have to, I might even bunt. If you are not fired up for the Yankees … I can’t wait, man. I want [Aaron] Judge to hit one down to third, I’m going to scoop it, I might look at him, and let’s go. I’m here to play, and I know he will take it with a grain of salt and we’ll go from there.

“I might put my hands together trying to get the crowd going, something. That’s just the way I’ve always been doing it. It will work out.’’

When you are on life support as a team it better work out.

Frazier also backed Callaway, who has been under fire for the Mets’ poor play.

“We’re 100 percent behind him,’’ Frazier said. “He’s made all the right decisions.’’

Callaway is no stranger to the Yankees — his Indians were beaten in the ALDS last October by them.

“The way we’ve been pitching I feel we can match up with anybody,’’ Callaway said. “We have the arms. We have the ability to elevate. I feel we match up well against their lineup. Now they have a great lineup. We have great pitching and our pitchers have been showing that lately.’’

To get off life support the Mets are going to have to shut down that Yankees superheroes lineup and finally find a way to create some offense.

If this homestand winds up with nine straight losses and then a 10-game road trip, you might as well pull the plug on the Mets’ season.