Johan Santana against Daisuke Matsuzaka on Friday night in the opener of a three-game series with the Red Sox promises to be the marquee matchup of the Mets’ first trip to Fenway Park since 2006. Here is the breakdown:

Friday — Santana (5-2, 1.36) vs. Matsuzaka (0-1, 12.79), 7:10 p.m., SNY.

Saturday — RHP Mike Pelfrey (4-1, 4.61) vs. RHP Josh Beckett (4-2, 5.85), 7:10 p.m., SNY and MLB Network.

Sunday — RHP Tim Redding (0-0, 3.00) vs. RHP Tim Wakefield (5-2, 3.59), 1:35 p.m., PIX-11 and TBS.