On a night that Vladimir Guerrero Jr. reiterated he will never wear pinstripes, the Yankees’ lineup looked particularly in need of his bat.

The Yankees do not have the Blue Jays star, Giancarlo Stanton or anyone who is rolling offensively right now.

The Yankees managed one meaningful swing, just five hits and no runs past the second inning in a 6-1, series-opening loss to the Blue Jays on Friday in front of 39,025 in The Bronx.

The Yankees (12-8) trailed by two runs three batters into the game, and the Blue Jays (12-8) never looked back in the first matchup of the season — one that got tense late between the AL East rivals.

Guerrero — the superstar who, shortly before first pitch, stated for a second time that he would never play for the Yankees for “personal” reasons — sure likes hitting at the Stadium regardless.

The slugger blasted his 11th home run in his 32nd career game in The Bronx, giving the Blue Jays an instant 2-0 lead that would never be threatened.

“We’re kind of grinding right now,” manager Aaron Boone said about the bats before adding, “We’re doing a lot of winning things, though, on offense.”

The 39,025 fans were loudest when Oswaldo Cabrera drilled a second-inning home run to bring the Yankees within one run, but there was little reason to cheer afterward. The Yankees managed two hits past the second inning.

The fans were second-loudest in the top of the ninth, when righty Greg Weissert hit Guerrero in the left elbow, prompting Guerrero to stare at Weissert and take off his equipment slowly at the plate. Guerrero glared at Weissert during a long walk to first base that was interrupted by Anthony Rizzo, who walked toward Guerrero and had some words.

“Just walk to first base,” Rizzo said he told Guerrero. “It wasn’t much more than that. I just took exception to that; wanted to back my teammate. Staring him down like that — it was obviously an accident.”

Weissert, pitching in his third game of the season and for a second day straight, walked two in his inning.

“Obviously I wasn’t trying to hit him,” said Weissert, who appreciated Rizzo’s defense. “I didn’t have my best stuff.”

The situation did not escalate, but it generated the most late-game noise from the crowd.

Through the first 19 games of the season, the Yankees fielded essentially a league-average offense, scoring the 15th-most runs in baseball. The bats would have loved to be average during Game 20.

The Yankees had two hits after the second inning, the first a fifth-inning single from Isiah Kiner-Falefa and the second a ninth-inning single from Aaron Judge. Neither made it to second base, both erased on double plays.

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“Had a couple chances in there,” said Boone, whose Yankees have scored fewer than four runs four times in their five games since Stanton went down with a hamstring strain. “But otherwise, couldn’t muster up [much].”

Yusei Kikuchi and three Blue Jays relievers shut down an offense that, apart from Thursday’s nine-run outburst against the Angels, has been quiet. By the end of the night, the only player in the Yankees’ lineup with an average above .272 was Anthony Rizzo.

“He was hitting his spots,” Rizzo said of Kikuchi. “He had his slider, cutter going strong. That cutter was really biting hard.”

The Yankees’ only run Friday arrived in the second, when Cabrera drilled an outside fastball over the right-field wall to bring the Yankees within one. It was Cabrera’s first homer of the season and a sign of hope: Entering play, Cabrera was 6-for-38 (.158) in his past 10 games.

Domingo German pitched better than his line (six innings with four runs allowed on four hits and two walks) but was burned by two misses. His first, to Guerrero, was a straight-down-the-pipe curveball that was blistered a projected 417 feet to left-center.

German settled down from there and retired 12 straight Blue Jays until walking Matt Chapman in the sixth inning. Two batters later, German made his second mistake, a middle-of-the-plate four-seamer that Brandon Belt hammered into the Yankees’ bullpen in right-center for his first home run of the season.

Belt, who entered play hitting .154, added a two-run double in the eighth against Albert Abreu that padded the Blue Jays’ lead.

Some tension would arrive an inning later, but not courtesy the Yankees’ bats.