A four-game sweep in Baltimore slipped further into the distance after the Yankees dropped a series in The Bronx to the White Sox, who came in 28 games under .500.

It sure seemed like a lost opportunity for the Yankees to gain ground — if not in the AL East, at least to pad their lead over the A’s for the top wild-card spot.

But after Wednesday’s 4-1 loss, Aaron Boone made it clear it didn’t matter who the opponent was.

“I walk in there [to the clubhouse] pissed off every night, whenever we lose,’’ Boone said. “It’s disheartening whoever it is against. I don’t get caught up in the opponent.”

And if it wasn’t for a stirring comeback late Tuesday, the Yankees might have been in even worse shape.

As it is, they were shut down by Reynaldo Lopez for the second time in a month. The right-hander outpitched CC Sabathia, as the Yankees fell 7 ½ games behind the Red Sox in the division.

“The bottom line is you’re gonna have some bumps where you lose to a team that maybe you don’t think we should lose to and that’s always frustrating,’’ Boone said. “The losses stink. As far as who it’s against, man, I don’t really care.”

When they did have a chance to get back in the game in the fifth, trailing by three runs, the Yankees scored just once.

Ronald Torreyes drove in the only run with a one-out bases-loaded single. Brett Gardner struck out for the second out, bringing up Giancarlo Stanton.

The Yankees appeared to get a break when Lopez’s pitch sailed over catcher Kevan Smith, but Smith raced back to the backstop to get it and Lopez made a terrific play at the plate to tag a sliding Gleyber Torres to end the inning with Stanton helpless in the batter’s box.

“You don’t expect a perfect bounce to [the catcher] and a perfect throw like that,’’ said Stanton, who went 0-for-3 with a walk as he continues to slump while looking for home run No. 300. “You can’t look back [at that play]. If he’s safe, it’s a great job. If he’s not, you look at all the negatives. It’s a good read. It sucks in that situation.”

The Yankees, who had a chance to go a season-high 37 games over .500, couldn’t repeat Tuesday’s late comeback that ended with Neil Walker’s game-winning homer in the bottom of the ninth.

Sabathia cruised through the first inning, striking out two, but the White Sox scored twice in the second.

With runners on the corners and two out, Ryan LaMarre hit one to the opposite field that just got over Stanton in right for a two-run double. It was the first of three extra-base hits by LaMarre, who drove in three runs.

The Yankees had just one base runner until the fifth, but Boone saw a slip in his team’s at-bats as the game progressed, as the Yankees didn’t get a runner into scoring position after the fifth.

“The first turn through the lineup, we had a lot of good swings with nothing to show for it,’’ Boone said. “But after that … we were a little inconsistent. It’s definitely a frustrating loss and one that we’ve got to get past here.”

It would help if Stanton could get going again at the plate, but he’s 6-for-38 with one extra-base hit since hitting his last home run.
Stanton continues to play just about every day, in the absence of Aaron Judge and Gary Sanchez.

He acknowledged a night off would be beneficial, but Stanton understands the situation.

“We’re beat up right now, so I’ve got to be a staple in there and help try to push through this hard time,” Stanton said. “We’re all tired, all beat up, but everyone else has played the same game, so you’ve got to keep pushing through.”