The Yankees officially placed Anthony Rizzo on the 10-day injured list Wednesday as the first baseman still is dealing with headaches that may be due to the epidural he received last week in California to treat his lower-back issues. The move was retroactive to Saturday.

DJ LeMahieu might not be far behind Rizzo in hitting the IL. His sore right big toe kept him out of the lineup again for both games of the doubleheader Wednesday against the Twins at Yankee Stadium.

“[A stint on the IL is] something we’re talking about with DJ,” manager Aaron Boone said before the Yankees swept the Twins, 5-4 in 12 innings and 7-1.

In his last 20 games, LeMahieu is 10-for-78 with no extra-base hits, and he is just 1-for-29 in his last eight games.

Boone repeatedly called the situation “complicated.”

LeMahieu is speaking with doctors about the best course of action and whether more time off would help the injury.

Boone said he spoke with Rizzo on Wednesday morning. According to the manager, Rizzo said he feels “great when I’m laying here,” but doctors want him to avoid activity until Thursday afternoon, following tests that were done Tuesday to find the cause of the headaches.

“We hope in the next 24-48 hours the headaches subside,’’ Boone said.

If they do and Rizzo remains symptom-free, he can prepare to return to the lineup.

Ronald Guzman got the start at first base for the first game Wednesday and went 0-for-5. Marwin Gonzalez started at first in the nightcap before Guzman came in for defense in the ninth inning.

Guzman was selected from Triple-A Scranton/Wilkes-Barre and added to the active roster (as well as the 40-man roster) on Wednesday, while right-hander Luke Bard was designated for assignment.

In his last 29 games with SWB, the lefty-swinging Guzman hit .370 with 13 doubles, eight homers, 25 RBIs and an OPS of 1.179.

Andrew Benintendi is also on the IL after surgery to repair the hook of his hamate bone went “as expected,” Boone said.

The Yankees are holding out hope the outfielder will be able to return by the postseason.

They are also hoping for the return of Matt Carpenter, who had his fractured left foot reexamined on Monday. That exam revealed that his foot hasn’t fully healed.

That means Carpenter, who became a centerpiece of the offense after he signed with the Yankees earlier this season, won’t be able to begin baseball activities yet.

Boone said Carpenter is scheduled to have another X-ray in a “week to 10 days” to see if the fracture has healed. Asked the best-case scenario, Boone said he still believes Carpenter could get back to the team this season.

Giancarlo Stanton, still dealing with a sore foot, was held out of both games. … Miguel Andujar was named the 29th man for the doubleheader. He started Game 1 in left field and went 0-for-4, but didn’t play in the nightcap.

Josh Donaldson was placed on the paternity list before the doubleheader. Because the Yankees already had Andujar on the roster, they replaced Donaldson with right-hander Deivi Garcia, who didn’t get into either game. After the doubleheader, both Andujar and Garcia were optioned back to Triple-A.

Once a top prospect, Garcia pitched terribly in the minors and with the Yankees last season and was sidelined with a hand injury earlier this season at Triple-A.

Garcia, who was moved to the bullpen with SWB after being promoted from Double-A Somerset, allowed two earned runs in five innings over a pair of outings following the move.

“He’s thrown the ball well the last couple times,” Boone said.

Nestor Cortes (groin) is returning from the IL to start Thursday and the rotation is close to another boost. Luis Severino started in what’s expected to be his final rehab appearance with Double-A Somerset on Wednesday before an anticipated return to the rotation. He allowed a first-inning homer, but retired the last 10 batters he faced in his four-inning, 45-pitch performance.

Lou Trivino was out with back spasms Wednesday. The right-hander has dealt with them before, according to Boone, who hopes to have him back on Thursday.

Zack Britton threw a scoreless inning, walking one, in a rehab appearance with SWB on Wednesday.

“We’ll see where we’re at from there,” Boone said of the lefty’s comeback from UCL surgery last year. Boone added Britton would need “at least several” outings at Triple-A before he’s a consideration to join the bullpen in The Bronx.

Isiah Kiner-Falefa made his first appearance at third base since 2020 in the opener. Oswald Peraza, just called up from Triple-A, got the start at shortstop and had another good game in the field, including a nice charging play on Jake Cave’s slow hopper in the ninth.

Kiner-Falefa followed with a good stab to his right on a hard grounder by former Yankee Gary Sanchez for the next out.