A big inning did in Gerrit Cole again.

It wasn’t the six-run nightmare of two weeks ago, or the five-run frame from the start before that. But it was enough to send the reeling Yankees to a 5-2 loss to the Blue Jays on Saturday at the Stadium.

Cole was booed as he left the mound in the fifth inning after he gave up four runs, partly due to his own fielding misstep. And he yelled and banged the dugout roof twice in impotent frustration.

“That error sucks. I made good pitches to [Alejandro] Kirk, but he just placed that fly ball between our defenders in left-center field. I made the pitches to get out of it, but at that point the damage had been done,” said Cole, who is lauded as an ace and paid to be a stopper. “It’s a tough one, it’s a frustrating ending there.”

It continued a concerning trend: Cole being unable to work his way out of a jam. Allowing a walk and his own uncharacteristically poor fielding set up a pair of two-run doubles by Jackie Bradley Jr. and Kirk.

“One of those innings that’s plagued him in a few outings, where it’s not like he’s getting hit all over the yard, but just a couple things that snowballed there,” manager Aaron Boone said with a shrug. “Gerrit is a very good fielding pitcher, so I know he’s frustrated with that.

“And then he loses his footing obviously on trying to get the out, and then Kirk got him on not a bad pitch either. He got it to where he wanted to, up above the zone. And that was the difference. So, frustrating inning there.”

That has becoming a trend for Cole, who was outdueling Mitch White and hadn’t allowed a hit through 4 ¹/₃ innings.

Cole entered his July 29 start against Kansas City with a 9-3 record and a 3.09 ERA. But he surrendered a five-run fifth inning to the Royals that night, then coughed up six runs in the first inning in his next start, against the Mariners on Aug. 3.

After those two starts, he settled in and allowed just a lone run in his next 22 ¹/₃ innings — until Saturday.

After striking out Matt Chapman looking, Cole allowed his first hit of the day, a double to Santiago Espinal, then paid for nibbling at the zone when he walked Danny Jansen. He then allowed Bradley’s double down the left-field line, and Raimel Tapia beat out shortstop Isiah Kiner-Falefa’s throw for an infield hit.

Then Vladimir Guerrero Jr. got another infield hit when Cole slipped in front of the mound while attempting to field the ball. Guerrero was called out, but the call was overturned on a challenge. Kirk’s double to left-center did the rest of the damage.

“It’s just one game at a time for us right now. So, in terms of what I feel like right now, I feel like I shouldn’t have frickin’ walked Jansen, and I should have friggin’ made that play,” Cole said. “And I’d feel less bad about it if we weren’t in the rut that we were, but I’d still feel bad about it. So that’s where I’m at.”