J.A. Happ remained away from the Yankees on Wednesday while he recovers from hand, foot and mouth disease, but manager Aaron Boone remained hopeful the lefty would be able to make his scheduled start against the Red Sox on Saturday.

“We’ll keep evaluating it every 12, 24 hours,” Boone said before the Yankees’ 7-5 loss to the Orioles in The Bronx. “I’m still optimistic that he’ll be able to pitch Saturday for us, but I think that will be a lot clearer over the next 24 hours.”

The Yankees reportedly called up Luis Cessa after Triple-A Scranton/Wilkes-Barre’s game Wednesday, because the right-hander is the next logical choice to start Saturday at Fenway if Happ is unable to go.

The Yankees limited Cessa to one inning in his start for SWB on Tuesday to make sure he was available for Saturday’s game. And, because Lance Lynn was needed for 4¹/₃ innings in Wednesday’s loss at the Stadium, he’s no longer an option if Happ isn’t cleared medically.

Boone said he talked to Happ on Wednesday morning and that the 35-year-old sounded better.

“He’s hoping it kind of peaked [Tuesday] night,” Boone said. “But, again, we’ll let the doctor examine him and see where he’s at.”

Happ was excellent in his debut with the Yankees on Sunday, limiting the Royals to one run in six innings.

The Yankees also appeared set to call up Luke Voit, the slugging first baseman they acquired over the weekend from St. Louis in exchange for lefty Chasen Shreve, according to the Times Leader of Scranton.

Voit spent most of the season at Triple-A, including SWB since joining the Yankees, but the right-handed bat could be used against Boston, which will start a pair of lefties — Brian Johnson and David Price — in the upcoming series.

The 27-year-old went 2-for-11 for the Cardinals this season, but has shown good power in the minors.