Perhaps nothing solves the Yankees’ problems more than a visit from the Twins.

Dealing with an endless array of injuries and having ended a West Coast swing with two straight losses, the Yankees again had little trouble with Minnesota on Friday night, opening a homestand with a 6-3 win against the team that entered with the best record in the majors.

But the Yankees still managed to lose yet another key piece to injury, this time James Paxton, who exited after just three innings due to left knee soreness.

The left-hander is due to undergo an MRI exam Saturday.

“It’s frustrating,” Paxton said. “I’m not too worried it’s a long-term thing. I’m looking forward to what’s going on.”

Paxton said he’d been dealing with the knee issue for most of the season, but it grew worse Friday on a cold, damp night in The Bronx and that led him to walk three in his brief outing.

“It was nagging me enough that I couldn’t execute my pitches,’’ said Paxton, who has been receiving treatment on the knee, but managed to pitch well after a rough debut with the Yankees, which came against the Twins.

As has often been the case this season, the Yankees managed to survive Paxton’s injury, at least for one night.

Jonathan Holder came on and tossed two perfect innings, as Holder, Adam Ottavino, Tommy Kahnle and Zack Britton combined to retire 14 in a row until Britton walked Jorge Polanco and allowed a two-run homer to Nelson Cruz in the eighth to make it 6-3.

By then, the Yankees’ offense had gotten two solo homers from Gary Sanchez, who has a team-high 10 home runs despite having missed time on the injured list with a strained calf.

“His power has been big for us this year,’’ manager Aaron Boone said.

The Yankees also got plenty of assistance from Minnesota, which hardly looked like a team that had the best record in baseball going into Friday.

Brett Gardner started the Yankees off with a hard liner to center that Byron Buxton misplayed and didn’t get a glove on. Gardner ended up at third after the three-base error and scored on Gleyber Torres’ hard grounder through the left side of the infield.

Paxton loaded the bases with one out in the second, but Ehire Adrianza hit a grounder up the middle that Tyler Wade and Torres turned into a nifty double play to get Paxton out of the jam.

With a 2-0 in the third, what should have been a routine double play turned into a mess when Torres booted an easy grounder to put runners on first and second with one out with Cruz coming to the plate.

A four-pitch walk to Cruz loaded the bases for Minnesota again, and C.J. Cron hit a sacrifice fly that was chased down by Gardner in center to cut the Yankees lead to 2-1.

Paxton got Marwin Gonzalez to line out to second, but needed 33 pitches to get through the inning, bringing him to 64 in three innings.
More miscues by the Twins, who have dropped 13 of 14 in The Bronx since 2015, led to two runs in the bottom of the inning, with the Yankees taking advantage of an error and a wild pitch by Kyle Gibson.

Sanchez’s first homer of the night, a towering shot to left in the fifth, increased the Yankees lead to 5-1. He smashed another two innings later, a laser into the left-field seats.

It resulted in another positive result for the Yankees, but it came at a familiar cost.

“He’s one of our best guys,’’ Ottavino said of Paxton. “We can’t afford to lose him for too long, but at this point we’re kind of used to it. … Guys who are healthy have a game to play every day and pay attention to that.’’