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It had to happen sometime: The Yankees lost their first series of the season Sunday, after pitcher Javier Vazquez gave up four runs in the fourth, paving the way for an 8-4 loss. Here, Vazquez is removed from the game by manager Joe Girardi with catcher Francisco Cervelli (L) and third baseman Alex Rodriguez (R) looking on. REUTERS

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Los Angeles Angels Brandon Wood hitsa two-run RBI double in the fourth inning. AP

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New York Yankees left fielder Marcus Thames can’t catch a ball hit by Los Angeles Angels’ Brandon Wood for a double in the fourth inning. UPI

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Los Angeles Angels second baseman Howard Kendrick slides into home in the fourth inning . EPA

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New York Yankees’ Jorge Posada hits a two run home run against the Los Angeles Angels in the second inning. UPI

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New York Yankees’ Jorge Posada’s home run also brought home Robinson Cano, right. UPI

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New York Yankees’ Mark Teixeira hits a pop fly in the ninth inning. UPI

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Los Angeles Angels center fielder Torii Hunter makes a catch on a ball hit by New York Yankees’ Alex Rodriguez in the eighth. UPI

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New York Yankees Robinson Cano is congratulated after hitting a solo home run off Angel pitcher Scott Kazmir in the sixth inning. AP

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So close! Alex Rodriguez misses the tag as Los Angeles Angels center fielder Torii Hunter steals third base. EPA

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Los Angeles Angels designated hitter Hideki Matsui gets a single in the seventh inning. UPI

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Los Angeles Angels’ Kendry Morales nails a a three-run homerun in the seventh, off off Yankees’ relief pitcher Damaso Marte. REUTERS

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Relief pitcher Damaso Marte reacts after giving up a 3-run home run. EPA

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New York Yankees starting pitcher Javier Vazquez buries his head in a towel after being removed from the game. REUTERS

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Los Angeles Angels’ Kendry Morales is congratulated by Torii Hunter, left, and Hideki Matsui, right, after hitting a 3-run home run in the seventh inning. UPI

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