MIAMI — Nestor Cortes has likely thrown his final pitch this season, delivering the latest body blow to the Yankees’ rotation. 

The left-hander landed back on the injured list Friday with a left rotator cuff strain, the same injury that recently sidelined him for two months.

Cortes is facing a three-to-four week shutdown from throwing, and with just about eight weeks left in the season, he will be hard-pressed to make it back in time. 

“It’ll probably be tough with that kind of timeline,” manager Aaron Boone said Friday before the Yankees opened a series against the Marlins at loanDepot Park. “I know they’re going to reevaluate in three weeks.

“You’re talking three-to-four weeks of no-throw and then essentially starting over from there with catch-play. So it’d be pretty difficult, but we’ll see where we are in a few weeks.” 

Cortes had just returned from the 60-day IL last Saturday, when he threw four strong innings against the Astros.

He felt more soreness than usual the day after he pitched, which led the Yankees to push him back an extra day for a scheduled start on Saturday against his hometown Marlins. 

But when he tried to throw a bullpen session here on Thursday, he could not, which led to an MRI exam that revealed another strain that was “a little bit more pronounced than the last time,” Cortes said. 

According to Cortes and Boone, surgery has not been discussed as an option at this point. 

Meanwhile, a rotation that entered spring training with the potential to be one of the best in the majors is now hanging by a thread as the Yankees try to climb back into a playoff spot. 

“It’s definitely tough,” Cortes said. “If we’re going to make a run at it, we need everybody healthy. Not only myself, but [Carlos] Rodon and all the other pitchers. It’s tough. I was really looking forward to pitching here, too, for the first time. 

“It’s tough to swallow this right now.” 

The Yankees’ rotation has been battered beyond Gerrit Cole and Clarke Schmidt. Rodon missed the first three months of the season with injuries, came back to make six inconsistent starts, and is now back on the IL with a hamstring strain.

Frankie Montas has missed all season after undergoing shoulder surgery in February and is not expected to make it back this year.

Domingo German is also done for the season after being placed on the restricted list last week to seek treatment for alcohol abuse.

And after missing the first seven weeks of the season with a lat strain, Luis Severino is still healthy but has been brutally ineffective when he does pitch. 

Now, the Yankees have little choice but to keep Severino in the rotation, with Randy Vasquez and Jhony Brito being called up from Triple-A to take the spots of the injured Rodon and Cortes. 

“It’s been tough,” Boone said. “Having guys start and … have a lot of incomplete seasons around injuries, it makes it challenging, but that’s part of it. You gotta deal with it and you gotta roll with it.

“It creates opportunities for other guys. We’ve seen the Britos and Vasquezes get some opportunities and fare pretty well. There’s nothing we can do about it but continue to move forward.” 

Though the timing of Cortes’ latest setback was personally disappointing — he grew up in nearby Hialeah, Fla., and was expected to pitch in front of a huge crowd of family and friends on Saturday — it also all but puts a cap on a lost season overall for the 28-year-old. 

Coming off a breakout All-Star campaign last year, Cortes sustained a hamstring injury on the eve of spring training, then pitched to a 5.16 ERA in 11 starts before landing on the IL in early June with his first shoulder strain.

He and the Yankees were encouraged by how he felt and looked in his return last Saturday, but it likely will prove to be the last time they see him pitch this season. 

“It’s hard to pinpoint something [that caused this],” Cortes said. “Probably a combination of a little bit of everything. I felt really good coming into [the Astros start]. I think just the added adrenaline and the fact that I felt so good allowed me to — I guess it was hard to gauge my limit.”