BALTIMORE — Even the teams with the might, muscle and high-end talent the Yankees possess can’t get away with too many mistakes.

On Monday, in the first game of a doubleheader against the putrid Orioles, the Yankees ran themselves out of a run in the third inning. First baseman Neil Walker failed to field a ground ball that could have been a double play, but instead went for a double that fueled the hosts’ sixth-inning rally. CC Sabathia admitted plate umpire John Tumpane’s inconsistent strike zone bothered him.

Those three things led to the Yankees to dropping a 5-4 decision to the 25-65 Orioles at Camden Yards.

The most exciting act by a Yankee was delivered by Clint Frazier, who broke his bat over his right thigh after striking out to end the eighth inning to end an 0-for-4, three-strikeout game.

“For a team that is really aggressive like the Orioles, I thought they did a good job laying off [Sabathia’s] cutter,’’ Aaron Boone said. “A lot of the pitches from the side looked like they were close and tight but they did a nice job of making him work.’’

Staked to a 3-0 lead via Giancarlo Stanton’s solo homer in the second and RBI singles from Aaron Judge and Didi Gregorius in the third, Sabathia gave up a two-run homer to Mark Trumbo in the fourth when he questioned a pair of 1-1 calls on Jonathan Schoop and Trey Mancini. In the fifth Sabathia looked at Tumpane, and the umpire put his hand up as if to say, “Enough.’’

Walker’s RBI single in the sixth pushed the lead to 4-2, but Danny Valencia, who was in a 0-for-25 slump, hit a 1-1 pitch for a three-run homer, and Sabathia was replaced by Jonathan Holder.

Sabathia refused to hint that Walker should have turned Schoop’s smash into a double play that would have erased Trumbo’s leadoff walk.

“That’s part of the game. That ball was hit hard. That’s part of it,’’ said Sabathia, who gave up five runs and seven hits in five-plus innings and fell to 6-4.

Granted, had Walker fielded Schoop’s grounder cleanly a double play was there to be turned. However, Sabathia’s outing wasn’t close to the previous two when he worked seven and six innings and gave up a total of three earned runs.

Even though the Yankees scored twice in the third, they missed a chance for more. Kyle Higashioka led off with a double against Jimmy Yacabonis, who made his second big-league start. Tyler Wade followed with a single that moved Higashioka to third. Aaron Hicks’ hard-hit grounder to Mancini resulted in the first baseman stepping on the bag and throwing home, where Higashioka was headed. That resulted in a rundown, on which Higashioka was tagged out.

Consecutive run-producing singles by Judge and Gregorius took some of the sting out of failing to score more.

Because Holder and A.J. Cole held the Orioles scoreless the Yankees had a chance in the ninth against lefty closer Zach Britton.

That chance increased when Miguel Andujar, hitting for Walker, greeted Britton with a single to center and went to second on a wild pitch. Brandon Drury’s ground out to the right side moved Andujar to third and brought the O’s infield in with Higashioka at the plate. He fanned on a 3-2 pitch and Britton sealed the victory when Brett Gardner, hitting for Wade, grounded out and end the game.