BALTIMORE — A rough road trip mercifully came to an end Wednesday afternoon, which turned into a terrible, horrible, no good, very bad day for the Yankees.

After Max Fried lasted just three innings, exiting early with what the team said was left elbow posterior soreness that will require imaging Thursday, the Yankees got one-hit in a 7-0 loss to the Orioles at Camden Yards.

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The clunker finished off a 1-5 trip against the Brewers and Orioles (20-24) — it technically continues this weekend against the Mets at Citi Field — as the Yankees (27-17) had another quiet day with the bats, getting suffocated by right-hander Kyle Bradish and three relievers.

“Just not a good day for us,” manager Aaron Boone said. “Had a chance to win a series and just got behind. Bradish threw the ball well, but we were just having a hard time mounting anything. Overall, not a great performance.”

The biggest concern was the health of Fried, who gave up three runs over three innings before Paul Blackburn and Ryan Yarbrough followed in relief and allowed the Orioles to break the game open.

But the offense offered no help, which was the case for most of the trip, scoring 14 runs in six games — two of them shutouts — and six of those runs coming in Tuesday’s win.

“It’s the ebbs and flow of the season,” Aaron Judge said. “Couple tough stretches. This series, not really getting a chance with too many guys on base. We got to take our walks when we can. [Tuesday] we came out swinging, took care of business, but you got to keep that going into the next game. … Just got to feed off each other. Not one guy can do it all, so once we get rolling here, it’s going to be special.”

The Yankees did not have a hit off Bradish until Jazz Chisholm Jr. roped a one-out double in the fifth inning, which proved to be their only one of the afternoon.

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Spencer Jones later worked a walk, which, along with a wild pitch, put runners on the corners with two outs for Anthony Volpe. But the shortstop was not able to come through in his season debut, working a full count before striking out on a curveball to end the threat.

Volpe, keeping the seat warm for the injured José Caballero, had a rough first game back, going 0-for-3 with a fielding error in the eighth inning on a ball to his left that he got to but then bobbled.

He was not alone, though, as the Yankees only had six base runners (five via walks) all day.

“It’s a tough road trip,” Judge said. “You’re going to have two or three of those during the year and it’s about how you respond. Nothing we can do about it now. We went into Milwaukee and they took care of business, a couple close games we could have won. Same thing here. Just a tough road trip, we got to respond when we get back to New York.”