BOSTON — It seemed like Jazz Chisholm Jr. was determined to exit Sunday night’s 5-4, 10-inning loss to the Red Sox well before it was over.

The second baseman, hitting leadoff for the first time this season, was tossed after striking out to end the top of the sixth for arguing a checked-swing third strike.

Chisholm was upset with home plate umpire Adam Hamari, who made the call and didn’t check with third base ump Clint Vondrak.

As Chisholm turned to argue vehemently with Hamari at the plate, first base coach Dan Fiorito raced to home plate to try to calm Chisholm, with manager Aaron Boone soon following from the dugout.

None of it stopped Chisholm from continuing to argue. When he slammed his helmet as Boone talked with Hamari, Chisholm finally was tossed by first base umpire Todd Tichenor, the crew chief.

“We tried to keep him in the game in that situation [and] tried to distract a little bit,” Boone said of his attempt to prevent the ejection. “They gave him a little bit of rope to argue his case, and the helmet going in a certain direction probably cost him.”

Chisholm was replaced in the lineup by Anthony Volpe, while José Caballero moved from short to second base.

“I never like when guys get tossed,’’ the manager said. “Everyone once in a while, a guy gets tossed. I don’t want him out of the game and tried to rein it in there.”

Boone added he thought the checked swing was “at least borderline. My quick view from the first base dugout was that he didn’t [swing].”

The Yankees — and Chisholm — lost that argument but still came back to tie the game in the top of the ninth and take the lead in the 10th before blowing it in the bottom of the 10th for their fourth straight defeat.

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When Chisholm was ejected, they still were being dominated by ex-Yankee Sonny Gray, as the right-hander didn’t allow a hit until the eighth.

For Chisholm, it was another low point in what’s been a rocky season. He got off to a rough start to the year with a .611 OPS through the end of April, but he was productive for most of May.

That was followed by a disappointing last three-plus weeks.

“I feel like he’s been solid now for a couple months, but I always feel like with Jazz, there’s so much more,” Boone said before the game. “[We’re] waiting for him to really catch fire. I feel like he hasn’t caught fire yet at all this year. I feel like after a really slow start the first few weeks, I feel like he’s been steady the last couple months. But you’re always waiting on that hot streak that you know he’s capable of.”