Quentin Grimes’ absence could last just one game. 

After he was held out of Wednesday’s loss to the Raptors because of a sprained right ankle, the second-year guard was upgraded to questionable for Friday night’s game against the Bulls at the Garden. 

Grimes was a game-time decision on Wednesday after being listed as doubtful and went through pregame warm-ups. Coach Tom Thibodeau has said he didn’t believe it was a long-term injury. 

Grimes has been a key part of the Knicks’ recent turnaround — averaging 11.3 points, 4.3 rebounds and shooting 40.6 percent from 3-point range since breaking into the starting lineup Nov. 20. 

Immanuel Quickley started in Grimes’ spot, scored 20 points and hit a season-high six 3-pointers in the loss. 

“It’s always [tough] when someone is out, especially him. He brings a lot of defense,” Quickley said. “He’s been guarding the best player on the [other] team pretty much all season. I stepped up as best I could, tried to guard Fred [VanVleet]. But QG’s a big part of this team — he brings shooting, athleticism, defense.” 

A nagging left foot injury sidelined Grimes for virtually the entire preseason and most of the first month of the regular season. 

It’s no longer a small sample size for RJ Barrett. Over the past 15 games, he is shooting a shade under 46 percent from the field, making 37.5 percent of his 3-point attempts and is averaging 21.7 points and six rebounds. He has turned a corner after a rough start to the season. 

“Just attacking downhill, getting to the rim,” Thibodeau said. “I think he’s starting to find a rhythm.” 

The Knicks face just two teams with a winning record over their next eight games — the 76ers on Christmas and Suns on Jan. 2. The other five teams (Spurs twice) in this soft stretch are a combined 32 games under .500.