Is it realistic to expect Daniel Jones to be ready, available and cleared to play in a few days after he reported Wednesday that his neck is “still a little bit sore,’’ and, on the advice of the Giants’ medical staff, he was held out of practice?

“I think it’s tough to say today,’’ Jones said, standing in front of his locker, moving his head from side to side with no discernable discomfort. “It has a lot to do with how I feel [Thursday] and the day after that.’’

The optimism Brian Daboll expressed Monday about Jones and his neck injury was replaced by a far different sentiment two days later.

“I’d just say let’s let it play out here,’’ Daboll said. “We’ll see how he is the next day, then the next day after that, and then I think we’ll take this all the way to the end of the week.’’

This does not bode well for Jones’ availability for Sunday’s game in Buffalo.

If he is unable to play, veteran backup Tyrod Taylor will make his first start for the Giants, who were installed as a two-touchdown underdog to the Bills with the assumption that Jones would play.

Jones spent the afternoon receiving treatment and not on the field with his teammates during the early practice periods, which is never a good sign.

When he missed the final six games of the 2021 season with a neck injury, Jones was at least on the field and throwing the ball around a bit.

“It’s a different injury, different circumstance,’’ Jones said.

Jones was forced out of Sunday’s 31-16 loss in Miami when he was sacked by outside linebacker Andrew Van Ginkel early in the fourth quarter.

Jones’ head snapped back as he took the heavy hit.

Daboll said Jones felt better the day after the game, but there was ongoing soreness and there will be no practice for Jones until the soreness subsides.

Also, whenever he is pain-free, Jones must be cleared for contact by the team’s medical staff.

There will be no rushing the starting quarterback — in the first year of a four-year, $160 million deal — onto the field.

The Giants are extremely banged up heading into a game against one of the NFL’s best teams.

Left tackle Andrew Thomas is almost definitely going to miss his fifth consecutive game with a strained hamstring.

Rookie center John Michael Schmitz (shoulder) is also not likely to return this week.

Running back Saquon Barkley practiced on a limited basis, and there is a chance Barkley returns and plays this weekend, after missing the past three games with a high ankle sprain.

Considering the Giants are one of the league’s worst offensive teams with Jones, the prospect of playing without him is daunting.

“Losing our starting quarterback would definitely be tough,’’ wide receiver Parris Campbell told The Post. “Then again, that’s why you have guys like Tyrod Taylor on the team. Obviously he’s a backup here but man, like, across the league, Tyrod could go lead a team. He’s gonna be prepared, he’s always prepared and locked in. Shoot, at the end of the day, he’s one of the oldest guys on the team, he’s been doing it for a while, he’s a vet’s vet. He carries himself that way.’’

Taylor’s most recent start was Dec. 5, 2021, when he was with the Texans, and it did not go very well — he was benched in the third quarter of an eventual 31-0 loss to the Colts.

Taylor, 33, is 26-25-1 as an NFL starter.

He appeared in just three games the entire 2022 season, but the Giants have been so bad this season that Taylor has been summoned four times to close out a lopsided loss.

“I don’t think it matters to me,’’ Taylor said, “Obviously the best experience is having experience in a game. Whether I played snaps or didn’t play snaps this year, execution is what it boils down to.’’

Taylor went 9-for-12 for 86 yards when he subbed in for the injured Jones in Miami, and nearly was forced from that game when he had the wind knocked out of him after taking a hit on a scramble.

The only other quarterback on the scene is Tommy DeVito, a rookie from Illinois who is on the practice squad.

Daboll said he and general manager Joe Schoen have discussed the possibility of adding a more experienced quarterback.

Jones said he has no concern that his second neck injury in two years is a warning about a possible long-term issue.

“Yeah, it feels different, it’s not the same injury,’’ Jones said, adding that the results of an MRI exam “wasn’t negative, necessarily.’’

Jones repeated over and over that his goal is to play Sunday.

“I think this is something I’ll be able to recover from quickly,’’ he said.

Quickly enough to not miss this game?