One week into his return from a high ankle sprain, figure Saquon Barkley breaks out against a suspect Lions run defense, and Daniel Jones, concentrating on ball security, will not put the ball on the ground as often as he has lately. Could come down to veteran quarterback Matt Stafford making a play down the stretch.

Lions 24, Giants 20

Lions DT Damon “Snacks’’ Harrison vs. Giants interior offensive line

This will not be a 3-on-1 battle between Will Hernandez, Jon Halapio and Kevin Zeitler taking on Harrison, but the guards and center will all get a crack at Snacks. It has not been a vintage year for Harrison, usually one of, if not the, premier run-stopper in the league.

Harrison says he is frustrated with his play, and the numbers show this to be true — the Lions are 28th in the NFL in run defense, allowing 139.2 yards per game on the ground. That is not supposed to happen with Harrison plugging everything up inside. Harrison, a former Giant, says he is not looking for revenge, and this is just another game to him, but you know he wants to show the Giants they made a mistake for trading him away and wants to put a few good licks on Saquon Barkley.

Familiar Faces: Raiding the Giants for defensive help is seemingly not a smart way to go, but the Lions have a distinct Giants feel to their defense, with three starters recently employed in East Rutherford, N.J. In addition to Damon “Snacks” Harrison at nose tackle, the Lions also have defensive end Romeo Okwara and linebacker Devon Kennard in their lineup.

“Those guys have been great,’’ Lions coach Matt Patricia said. “Great guys to come into our system and picked it up pretty quick.’’

The Long Ball: Matt Stafford has 26 completions this season of 21 or more yards, tied for sixth-most in the NFL. He can chuck it. Of Stafford’s 218 attempts, 88 of them have resulted in a first down, a 40.4 percent clip that is third-highest in the league. He has 13 touchdown passes, just three interceptions and could torch a Giants pass defense that is ranked No. 23.

“His arm, he has a big-time arm, he is one of the best throwers in the league,’’ said linebacker Markus Golden, who leads the Giants with five sacks. “He can throw the ball real far and has confidence to throw the ball far.’’

Evan Almighty? As returns go, this one was a dud. Tight end Evan Engram, coming back after missing one game with a sprained knee, played 59 of the 71 offensive snaps last week and did not do much. He had five passes thrown his way and caught only one, for 6 yards, and as a blocker was beaten badly on one of Chandler Jones’ four sacks.

“There was a lot of mistakes that we put on film,’’ Engram said. “We’re a real transparent team, we’re real tough on ourselves. We understand there are things we have to fix individually and as a team.’’

All for none: The Lions were 2-0-1 after victories over the Chargers and Eagles, a nice early-season surprise team in the NFC. Three straight losses and, just like that, the trade of popular, respected veteran safety Quandre Diggs to the Seahawks angered his former teammates. Cornerback Darius Slay took to Twitter to post “WTF’’ and added “This is some bull s— here.’’ Slay this week told the Detroit News, “Anybody can get traded. I personally wouldn’t care.’’ To complicate matters — and this should be sweet music to the ears of Daniel Jones — Slay has a hamstring issue and will not play.

For more on the Giants, listen to the latest episode of the “Blue Rush” podcast: