The one true genius Patrick Graham knows of is Albert Einstein.

But the Nobel Prize-winning physicist never had to scheme up a way to replace a football team’s best player at its otherwise weakest position. That’s Graham’s challenge Sunday as the heralded Giants defensive coordinator tries to limit the impact of losing cornerback James Bradberry, who can’t add to his NFL-best 17 passes defended from the reserve/COVID-19 list.

The most likely solution is for the Giants to borrow from safety depth by having Julian Love return to his cornerback roots.

“Whatever coverage you call, you are pulling from weakness to play for a strength,” Graham said. “You’re trying to guess right as you try to defend the field. Playing defensive football, you’re trying to hedge your bets on most plays anyway, because there is so much field to defend. You can’t defend it all technically.”

Bradberry was deemed a high-risk close contact after he saw a chiropractor away from the team facility who tested positive for COVID-19. Though he is participating in virtual meetings from quarantine, Bradberry cannot return to the Giants until Monday at the earliest — provided he does not test positive or display any symptoms.

The Giants stress players should use their team-affiliated trainers and doctors to avoid this exact breach in protocol.

“If someone is external, we’ve talked to our players repeatedly and re-emphasized — I don’t care if it’s a chiropractor or a dentist or a barber — get them in our system,” coach Joe Judge said. “We’ll get them tested. We’ll make sure you’re safe.”

Bradberry’s absence coincides with, but is not related to, offensive coordinator Jason Garrett’s positive test result. Garrett will be out for 10 days.

“James wasn’t defiantly doing anything. He didn’t do anything malicious to hurt the team,” Judge said. “Sometimes you make a mistake. I don’t want to speak for James, but I can echo that his assumption of this guy was he was with another NFL team and he was under the assumption that he was tested every day. What we can’t do as a team is make those assumptions.”

The Giants also will be without starting slot cornerback Darnay Holmes (knee) for a second straight game, leaving Isaac Yiadom — who has played every snap over the last six games after a three-game benching — as the only healthy option. Jets cast-off Quincy Wilson and rookie Jarren Williams are expected to be promoted from the practice squad.

But the preferred option is for the Giants to move Love to the perimeter opposite Yiadom. He is the fourth safety behind Jabrill Peppers, Logan Ryan and Xavier McKinney. The rookie McKinney and Love filled in for Holmes in the slot last week.

The Giants turned Love into a safety as a rookie because of speed concerns, but he was a top cornerback at Notre Dame.

“We have the utmost faith in Julian,” Peppers said. “He’s been getting reps at corner for quite a while this year, just in case. That’s what he did in college. He was a Jim Thorpe [Award] finalist for a reason. He’s a sure tackler out there, and we know he’s going to compete. It sucks losing James, but next man up.”